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- Title
- Base Promoted 5-endo-dig Cyclizations of Non-Conia-ene Propargyl Ethers: A Mechanistic Investigation.
- Creator
- Hintze, Silas Q., Lepore, Salvatore D., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
Herein, we discuss a novel method for the synthesis of decorated 2,5-dihydrofurans. The base promoted 5-endo-dig cyclization of non-Conia-ene propargyl ethers produces 2,2 disubstituted dihydrofurans. Central to the reaction is the presence of an acidic C–H bond which is activated by an adjacent aromatic heterocycle. The transformation is viable with a wide range of substituents, including N, O, and S containing heterocycles, substituted phenyl rings, and alkyl groups. The cyclization...
Show moreHerein, we discuss a novel method for the synthesis of decorated 2,5-dihydrofurans. The base promoted 5-endo-dig cyclization of non-Conia-ene propargyl ethers produces 2,2 disubstituted dihydrofurans. Central to the reaction is the presence of an acidic C–H bond which is activated by an adjacent aromatic heterocycle. The transformation is viable with a wide range of substituents, including N, O, and S containing heterocycles, substituted phenyl rings, and alkyl groups. The cyclization proceeds within 30 seconds at room temperature under the action of potassium tert-butoxide. This work stands apart from the current literature due to the absence of transition metal catalysts and/or harsh reaction conditions. A thorough mechanistic investigation is undertaken to better understand the nature of this unprecedented reaction.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014376
- Subject Headings
- Cyclization (Chemistry), Chemistry, Organic
- Format
- Document (PDF)
- Title
- SYNTHESIS OF TUMOR-ASSOCIATED MUC1 GLYCOPEPTIDES AND THEIR LECTIN BINDING ASSESSMENT BY ITC.
- Creator
- Ayyalasomayajula, Ramya, Cudic, Mare, Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
In recent decades, developments in glycobiology have enabled the use of glycopeptides as tools for studying complex diseases such as cancer. Mucin 1 (MUC1) is a heavily glycosylated transmembrane protein, altered in both expression and glycosylation pattern in human carcinomas of the epithelium. The presence of incomplete or truncated glycan structures, often capped by sialic acid, commonly known as tumor-associated carbohydrate antigens (TACAs), on the cell surface is a well-known cancer...
Show moreIn recent decades, developments in glycobiology have enabled the use of glycopeptides as tools for studying complex diseases such as cancer. Mucin 1 (MUC1) is a heavily glycosylated transmembrane protein, altered in both expression and glycosylation pattern in human carcinomas of the epithelium. The presence of incomplete or truncated glycan structures, often capped by sialic acid, commonly known as tumor-associated carbohydrate antigens (TACAs), on the cell surface is a well-known cancer biomarker and therapeutic target for different types of cancer. Accumulating evidence suggests that TACAs are recognized by the endogenous carbohydrate binding proteins (lectins). These interactions frequently result in the development of a protumor microenvironment, favoring tumor initiation, progression, metastasis, and immune evasion. Macrophage galactose binding lectin (MGL) is a C-type lectin receptor found on antigen-presenting cells (APCs) which facilitates the uptake of carbohydrate antigens for antigen presentation, modulating the immune response in homeostasis, autoimmunity, and cancer. Considering the crucial role of tumor-associated forms of MUC1 and MGL in tumor immunology, a thorough understanding of this interaction is essential for it to be exploited for cancer vaccine strategies. The specific goal of this research is to synthesize structurally well-defined chemical probes, mono and multiple glycosylated MUC1 glycopeptide models bearing the Tn or sTn antigens, that provide control over the complexity of the chemical space of multivalent ligands. For this purpose, a concise scheme was developed for the large-scale synthesis of the Tn and sTn antigen building blocks in a relatively high yield with moderate stereoselectivity. Thiophenyl glycoside donors, in the presence TfOH/NIS or TMSOTf/NIS as promoter systems, were used for the galactosylation and sialylation steps of the amino acid building block synthesis, respectively. We explored the effect of the activator, temperature, solvent, and excess equivalent of sialic acid thioglycoside donor on the sialylation reaction.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014463
- Subject Headings
- Mucin-1, Glycopeptides, Cancer, Immune Evasion
- Format
- Document (PDF)
- Title
- THE EFFECT OF RESISTANCE TRAINING VOLUME ON INDIVIDUAL-LEVEL SKELETAL MUSCLE ADAPTATIONS.
- Creator
- Robinson, Zac P., Zourdos, Michael C., Florida Atlantic University, Department of Exercise Science and Health Promotion, Charles E. Schmidt College of Science
- Abstract/Description
-
Purpose: This study examined inter-individual response variation in muscle size and strength following training with different resistance training (RT) volumes. We hypothesized that despite clear gross variability, we would not detect clear evidence of inter-individual response variation for the primary outcomes. Additionally, we hypothesized that higher weekly set volumes would benefit muscle hypertrophy but not strength outcomes at the group-level. Methods: Sixteen recreationally trained...
Show morePurpose: This study examined inter-individual response variation in muscle size and strength following training with different resistance training (RT) volumes. We hypothesized that despite clear gross variability, we would not detect clear evidence of inter-individual response variation for the primary outcomes. Additionally, we hypothesized that higher weekly set volumes would benefit muscle hypertrophy but not strength outcomes at the group-level. Methods: Sixteen recreationally trained individuals had their lower limbs randomized into either a low (LV = 8 sets per week) or high volume (HV = 16 sets per week) training condition for an initial 11-week intervention (phase 1). After a washout period, a second identical 11-week intervention (phase 2) was conducted with limbs re-randomized to the training conditions. Primary outcomes measured were vastus lateralis (VL) cross-sectional area (CSA), muscle thickness (MT), leg press one-repetition maximum (1RM), and isometric force (MVIC) at baseline, midpoint, and post-intervention for each phase. Results: Higher RT volumes benefited muscle hypertrophy (CSA = 2.04 cm2 [95% HDI: 0.11, 3.81], MT = 0.55 mm [95% HDI: -0.06, 1.19]) to a larger degree than strength outcomes (1RM = 4.05 kg [95% HDI: -1.67, 10.14], MVIC = 0.66 kg [95% HDI: -3.83, 5.07]) at the group-level. Clear gross variability was observed for all primary outcomes, but we did not detect strong evidence in support of true inter-individual response variation (CSA = 0.17 cm2 [95% HDI: 0, 3.54], MT = 0 mm [95% HDI: 0, 1.1], 1RM = 0.59 kg [95% HDI: 0, 7.92], MVIC = 4.49 kg [95% HDI: 0, 9.43]).Conclusion: Higher volumes appear to benefit muscle hypertrophy but not strength at the group-level. Additionally, we failed to detect strong evidence of interindividual response variation to different RT weekly set volumes, despite clear gross variability.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014452
- Subject Headings
- Isometric exercise, Muscles, Sports sciences, Vastus lateralis
- Format
- Document (PDF)
- Title
- QUANTIZATION OF CONSTANTLY CURVED TETRAHEDRON.
- Creator
- Hsiao, Chen-Hung, Han, Muxin, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
-
Quantum tetrahedron is a key building block in the theory of Loop Quantum Gravity (LQG) and plays a crucial role in the boundary states of the spinfoam amplitude of LQG. In LQG with vanishing cosmological constant, the physical Hilbert space of the quantum at tetrahedron is the 4-valent SU(2) intertwiner space labeled by irreducible representation, each assigned to a face of the quantum at tetrahedron. Furthermore, the space is the solution space of the quantum at closure condition. The area...
Show moreQuantum tetrahedron is a key building block in the theory of Loop Quantum Gravity (LQG) and plays a crucial role in the boundary states of the spinfoam amplitude of LQG. In LQG with vanishing cosmological constant, the physical Hilbert space of the quantum at tetrahedron is the 4-valent SU(2) intertwiner space labeled by irreducible representation, each assigned to a face of the quantum at tetrahedron. Furthermore, the space is the solution space of the quantum at closure condition. The area spectrum of each face of the quantum at tetrahedron is discrete and is characterized by a spin label. Classically, the correspondence between a set of solutions of at closure condition and at tetrahedron is guaranteed by the Minkowski theorem. This theorem has been generalized to the curved case, where a curved closure condition applies. The curved Minkowski theorem allows us to reconstruct homogeneously curved tetrahedra (spherical or hyperbolic tetrahedra) from a family of four SU(2) holonomies that satisfy the curved closure condition Although the quantization of the closure condition for a at tetrahedron has been extensively studied in LQG, the quantization of the curved closure condition and curved tetrahedron has not been explored yet. The homogeneously curved tetrahedron has played an important role in the recent construction of the spinfoam model with cosmological constant in 3+1 dimensional LQG. It is anticipated that the quantization of a curved tetrahedron should deFIne the building block for the boundary Hilbert space of the spinfoam model.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014446
- Subject Headings
- Quantum physics, Quantum theory, Quantum gravity, Tetrahedra
- Format
- Document (PDF)
- Title
- DEVELOPING AMINE-MODIFIED SILICA MATERIALS FOR CARBON DIOXIDE CAPTURE FROM DIFFERENT GAS STREAMS.
- Creator
- Ahmadian, Amirjavad Hosseini, Lashaki, Masoud Jahandar, Florida Atlantic University, Department of Civil, Environmental and Geomatics Engineering, College of Engineering and Computer Science
- Abstract/Description
-
The atmospheric concentration of CO2 increased from 320 to 425 parts per million by volume (ppmv; 0.0425 vol.%) between 1960 and 2024. Sample CO2 reduction strategies include shifting to renewable energy sources and employing CO2 capture. CO2 capture from the air (also known as direct air capture; DAC) has recently received increased attention. CO2 has the potential to act as an asphyxiant at high concentrations, particularly in enclosed environments (e.g., spacecraft, submarines), requiring...
Show moreThe atmospheric concentration of CO2 increased from 320 to 425 parts per million by volume (ppmv; 0.0425 vol.%) between 1960 and 2024. Sample CO2 reduction strategies include shifting to renewable energy sources and employing CO2 capture. CO2 capture from the air (also known as direct air capture; DAC) has recently received increased attention. CO2 has the potential to act as an asphyxiant at high concentrations, particularly in enclosed environments (e.g., spacecraft, submarines), requiring air revitalization to remove CO2. Hence, the U.S. Occupational Safety and Health Administration determined a permissible exposure limit of 5,000 ppmv CO2 (0.5 vol.%) throughout an 8-hour work shift. Considering the trace levels of CO2 and the presence of humidity in DAC and air revitalization applications, similar materials can be developed for implementation in both cases. CO2 capture involving amine-functionalized silica materials (“aminosilicas”) can achieve high CO2 uptakes at low concentrations due to high selectivity. Additionally, moisture in CO2-laden gases enhances the CO2 uptake and stability of aminosilicas. Therefore, this research investigated the potential of aminosilicas for removing CO2 from dilute streams, including DAC and air revitalization applications. Aminosilicas were produced using mesoporous silica supports with different particle sizes that were modified with tetraethylenepentamine (TEPA) or branched polyethylenimine (PEI) with different molecular weights (600, 1200, and 1800), or grafted with 3-aminopropyltrimethoxysilane (APTMS). The performance of aminosilicas was assessed to determine equilibrium CO2 adsorption capacity, adsorption kinetics, and cyclic stability.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014479
- Subject Headings
- Carbon dioxide mitigation, Adsorption
- Format
- Document (PDF)
- Title
- INTEGRATING GEOSPATIAL ANALYSIS AND TRAFFIC SIMULATION TO MODEL FLOOD IMPACTS IN RURAL AREAS.
- Creator
- Reginato, Attilio Junior, Kaisar, Evangelos I., Florida Atlantic University, Department of Civil, Environmental and Geomatics Engineering, College of Engineering and Computer Science
- Abstract/Description
-
This study aims to address the unique challenges of transportation in rural and disconnected communities through innovative data-driven methodologies. The primary methods employed in this research involve Geographic Information Systems (GIS) tools and simulation techniques to model and assess the impact of flood zones on rural traffic dynamics. The study recognizes the distinct mobility patterns and limited infrastructure prevalent in rural areas, emphasizing the need for tailored solutions...
Show moreThis study aims to address the unique challenges of transportation in rural and disconnected communities through innovative data-driven methodologies. The primary methods employed in this research involve Geographic Information Systems (GIS) tools and simulation techniques to model and assess the impact of flood zones on rural traffic dynamics. The study recognizes the distinct mobility patterns and limited infrastructure prevalent in rural areas, emphasizing the need for tailored solutions to manage flood-induced disruptions. By leveraging GIS tools, the study intends to spatially analyze existing transportation networks, population distribution, flood-prone areas, and key points of interest to formulate a comprehensive understanding of the local context. Simulation-based approaches using the PTV VISSIM platform will be employed to model and assess various flood scenarios and their effects on traffic flow and accessibility. This study’s outcomes aim to contribute valuable insights into improving accessibility, efficiency, and safety in transportation for these underserved areas during flood events. By combining GIS tools and simulation techniques, this research seeks to provide a robust framework for data-driven decision-making and policy formulation in the realm of rural and disconnected community mobility, particularly in the context of flood risks.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014472
- Subject Headings
- Rural transportation, Geospatial data, Floods, Urban planning
- Format
- Document (PDF)
- Title
- INTERGENERATIONAL INTERCHANGEABLE FORMS OF MALTREATMENT WITHIN FAMILIES.
- Creator
- Haggar, Katherine, Backstrom, Laura, McConnell, William, Florida Atlantic University, Department of Sociology, Dorothy F. Schmidt College of Arts and Letters
- Abstract/Description
-
In 2022, there were about 4,276,000 referrals to Child Protective Service (CPS) agencies within the United States in regard to 7,530,000 children (U.S. Department of Health & Human Services 2024: xii). Of these allegations there are 558,899 victims of child maltreatment (U.S. Department of Health & Human Services 2024: xii). One risk factor for child maltreatment is having a caregiver who has experienced victimization. Although there are many other risk factors for child maltreatment, this...
Show moreIn 2022, there were about 4,276,000 referrals to Child Protective Service (CPS) agencies within the United States in regard to 7,530,000 children (U.S. Department of Health & Human Services 2024: xii). Of these allegations there are 558,899 victims of child maltreatment (U.S. Department of Health & Human Services 2024: xii). One risk factor for child maltreatment is having a caregiver who has experienced victimization. Although there are many other risk factors for child maltreatment, this research highlights a caregiver having been maltreated and then the type of maltreatment experienced (either physical abuse or sexual abuse) as main areas of study. Results highlight that both physical and sexual abuse are found to increase the risk for other forms of maltreatment, while physical abuse increases the risk for both physical abuse and other forms of maltreatment. This research also continues by examining the type of maltreatment experienced and a child’s likelihood to engage in specific types of deviant behavior (petty, non-violent, and violent delinquency). Results show that physical abuse, sexual abuse, neglect, and emotional abuse increase the risk for petty and non-violent delinquency (partaking in criminal actions). Neglect, emotional abuse, and drug or alcohol abuse increase the risk of having been arrested by age 18.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014462
- Subject Headings
- Child abuse, Child sexual abuse, Child welfare
- Format
- Document (PDF)
- Title
- PARAMETERIZATION OF INVARIANT CIRCLES IN MAPS.
- Creator
- Blessing, David Charles, James, J. D. James, Florida Atlantic University, Department of Mathematical Sciences, Charles E. Schmidt College of Science
- Abstract/Description
-
We explore a novel method of approximating contractible invariant circles in maps. The process begins by leveraging improvements on Birkhoff's Ergodic Theorem via Weighted Birkhoff Averages to compute high precision estimates on several Fourier modes. We then set up a Newton-like iteration scheme to further improve the estimation and extend the approximation out to a sufficient number of modes to yield a significant decay in the magnitude of the coefficients of high order. With this...
Show moreWe explore a novel method of approximating contractible invariant circles in maps. The process begins by leveraging improvements on Birkhoff's Ergodic Theorem via Weighted Birkhoff Averages to compute high precision estimates on several Fourier modes. We then set up a Newton-like iteration scheme to further improve the estimation and extend the approximation out to a sufficient number of modes to yield a significant decay in the magnitude of the coefficients of high order. With this approximation in hand, we explore the phase space near the approximate invariant circle with a form numerical continuation where the rotation number is perturbed and the process is repeated. Then, we turn our attention to a completely different problem which can be approached in a similar way to the numerical continuation, finding a Siegel disk boundary in a holomorphic map. Given a holomorphic map which leads to a formally solvable cohomological equation near the origin, we use a numerical continuation style process to approximate an invariant circle in the Siegel disk near the origin. Using an iterative scheme, we then enlarge the invariant circle so that it approximates the boundary of the Siegel disk.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014464
- Subject Headings
- Dynamical systems, Nonlinearity (Mathematics), Numerical analysis, Parameterization
- Format
- Document (PDF)
- Title
- THE TEAR THAT NEVER REACHES THE GROUND.
- Creator
- Albert, Leslie Deborah, Velasquez, Joseph, Florida Atlantic University, Department of Visual Arts and Art History, Dorothy F. Schmidt College of Arts and Letters
- Abstract/Description
-
My fascination with the human figure remains a prominent part of my work as a familiar and complex path to formalist traditions. But as I have sought to expand my engagement with representational figuration, I look towards themes of universal emotions and conditions - grief, remembrance, anger, affection and resolve. Within this, I often allude to socio-political content, art historical references or personal experiences. In integrating representational figuration with a contemporary approach...
Show moreMy fascination with the human figure remains a prominent part of my work as a familiar and complex path to formalist traditions. But as I have sought to expand my engagement with representational figuration, I look towards themes of universal emotions and conditions - grief, remembrance, anger, affection and resolve. Within this, I often allude to socio-political content, art historical references or personal experiences. In integrating representational figuration with a contemporary approach, I incorporate techniques of drawing, painting and printmaking into narrative formats while preserving the figure as the protagonist. I lean into gestural lines, expressive marks and abstract color fields to breathe life into the work and enhance the emotive context. I embrace the intuitive process as I believe it reflects and retains a certain spiritual spontaneity and response. Recently, I have experienced deep loss. It is the grief associated with this that has informed these pieces. Grief is a process that can be present, historical, anticipatory or prolonged. I have been stricken by a wide range of losses –personal, societal, political and cultural - death of loved ones, risk of severe limitations to civil liberties and bodily autonomy, global wars and violence, xenophobia, brutal attacks on democratic ideals and even the inevitable passage of time have precipitated my personal and visceral grief.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014445
- Subject Headings
- Art, Fine arts, Figurative art
- Format
- Document (PDF)
- Title
- Toxic Peptides and Tubular Pili of Bloom-Forming Cyanobacteria.
- Creator
- Ricca, John G., Louda, J. W., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
Cyanobacteria are ancient prokaryotes that use photosynthesis and an accumulation of other adaptations to dominate aquatic ecosystems around the world. They are thus major contributors to biogeochemical cycling, a threat to human and environmental health, and an intriguing source for novel chemistry. We begin by providing an overview of bloom-forming cyanobacteria and their many toxic metabolites. We then discuss the characterization of some abundant extracellular pili of Microcystis...
Show moreCyanobacteria are ancient prokaryotes that use photosynthesis and an accumulation of other adaptations to dominate aquatic ecosystems around the world. They are thus major contributors to biogeochemical cycling, a threat to human and environmental health, and an intriguing source for novel chemistry. We begin by providing an overview of bloom-forming cyanobacteria and their many toxic metabolites. We then discuss the characterization of some abundant extracellular pili of Microcystis aeruginosa, reporting a 2.4 Å cryoelectron microscopy pilus structure, revealing a novel class of pili that we have termed cyanobacterial tubular (CT) pili. The CT pili in M. aeruginosa were determined to be multi-functional, with a primary role in networking cells and enhancing colony formation, but also in controlling colony buoyancy, enriching iron, and accumulating toxins in the extracellular mucilage. Lastly, we explore the potential of heavy-labeling cyanobacterial cultures for the sake of isolating natural products that can be studied by vibrational spectroscopic imaging. The vibrational spectra of three classes of cyanopeptides along with their heavy-labeled counterparts are reported, and Density Functional Theory calculations are used to describe mode character, clarifying some unexpected changes in vibrational spectra upon heavy-labeling. As a whole, this work offers new insight into cyanobacterial physiology as well as a means to study cyanopeptides with imaging techniques and stable-isotope labeling.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014490
- Subject Headings
- Cyanobacteria, Biogeochemical cycles, Microcystis aeruginosa
- Format
- Document (PDF)
- Title
- IDENTIFYING EPIGENETIC MODIFICATIONS TO COMBAT RESISTANCE TO THE CHEMOTHERAPEUTIC AGENT DOXORUBICIN.
- Creator
- Kingham, Anna Lesley, Grant, Patrick, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
- Abstract/Description
-
There has been substantial progress in cancer research that has markedly enhanced patient outcomes. However, chemotherapy resistance persists and often leads to multidrug resistance, rendering cancer cells unresponsive to multiple chemotherapy drugs, presenting a significant challenge in the effective treatment of the disease. Dysregulation in gene expression patterns caused by abnormalities in epigenetic mechanisms have been identified as contributing factors to the development and...
Show moreThere has been substantial progress in cancer research that has markedly enhanced patient outcomes. However, chemotherapy resistance persists and often leads to multidrug resistance, rendering cancer cells unresponsive to multiple chemotherapy drugs, presenting a significant challenge in the effective treatment of the disease. Dysregulation in gene expression patterns caused by abnormalities in epigenetic mechanisms have been identified as contributing factors to the development and progression of cancer. Epigenetic research offers potential to discover drugs that target specific epigenetic modifications to regulate gene expression patterns in the context of chemotherapy resistance. I hypothesize that histone modifications on histone H3 and histone H4 contribute to doxorubicin resistance. The data presented here provides an initial screening of the mutant monoallelic histone yeast strains to identify post-translationally modifiable amino acids in H3 and H4 that could contribute to doxorubicin resistance. The possible targets of histone modifications were then repeated in triplicate to obtain statistical significance. Finally, Western blot techniques were used to identify the modification occurring on the histone H3 and histone H4 amino acid sites that were previously identified to be statistically significant.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014473
- Subject Headings
- Epigenetics, Doxorubicin, Chemotherapy
- Format
- Document (PDF)
- Title
- HYPOXIA CHALLENGES IN ESTUARINE ENVIRONMENTS: EFFECTS ON EARLY FISH DEVELOPMENT AND LIPID UTILIZATION.
- Creator
- Kostelnik, Magaleate, Mejri, Sahar, Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
-
The distribution and intensity of hypoxia (low dissolved oxygen, DO) is increasing due to eutrophication and algal blooms in estuaries like those in the Gulf of Mexico and the Indian River Lagoon. The objective of this study is to determine how low DO affects the development and lipid utilization of the Florida Pompano (Trachinotus carolinus) and Red Drum (Sciaenops ocellatus). Fertilized eggs were incubated in two DO hypoxia treatments: severe (20% DO saturation, 1.6 mg/L), moderate (50% DO...
Show moreThe distribution and intensity of hypoxia (low dissolved oxygen, DO) is increasing due to eutrophication and algal blooms in estuaries like those in the Gulf of Mexico and the Indian River Lagoon. The objective of this study is to determine how low DO affects the development and lipid utilization of the Florida Pompano (Trachinotus carolinus) and Red Drum (Sciaenops ocellatus). Fertilized eggs were incubated in two DO hypoxia treatments: severe (20% DO saturation, 1.6 mg/L), moderate (50% DO saturation, 3.9 mg/L), and normoxia (100% DO saturation, 7.6 mg/L). Eggs and larvae were sampled at 24-hours post-fertilization to assess hatch survival, larval development, and fatty acid (FA) lipids utilization. Results suggest hypoxia significantly impacts Florida Pompano development, with polar FAs most affected, while Red Drum shows greater tolerance to low DO. These findings provide insight into early fish larval stages to improve conservation and management strategies for their recruitment.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014455
- Subject Headings
- Hypoxia, Florida pompano, Red drum, Fishes--Larvae, Fishes--Development
- Format
- Document (PDF)
- Title
- GABAERGIC NEUROTRANSMISSION AND POTENTIAL RESCUE METHODS FROM CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHIES IN C. ELEGANS.
- Creator
- Gonzalez-Lerma, Paola X., Dawson-Scully, Kenneth, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
- Abstract/Description
-
Cancer is a leading cause of death in the U.S and across the world, with estimates indicating 17 million new cancer cases in 2018, 9.5 million of which resulted in death. Statistics show that in the past 20 years cancer death rates have decreased 27% due to emerging therapies. The use of chemotherapies to kill fast-growing cells in the body has become one of the most common cancer treatments in the world today. Chemotherapy-Induced Peripheral Neuropathies (CIPNs) are the most common side...
Show moreCancer is a leading cause of death in the U.S and across the world, with estimates indicating 17 million new cancer cases in 2018, 9.5 million of which resulted in death. Statistics show that in the past 20 years cancer death rates have decreased 27% due to emerging therapies. The use of chemotherapies to kill fast-growing cells in the body has become one of the most common cancer treatments in the world today. Chemotherapy-Induced Peripheral Neuropathies (CIPNs) are the most common side effects caused by chemotherapeutic agents. CIPNs have a prevalence of up to 85% in cancer patients undergoing chemotherapy. CIPNs triggered by chemotherapeutic drug use severely damage nerves branching from either the brain or spinal cord, initiating the development of acute and/or chronic symptoms. Platinum-based and taxane-based chemotherapeutics are among the most potent and versatile drugs available for combating cancer. The two of these drugs, carboplatin and docetaxel, are known to cause peripheral neuropathies and central neurotoxicity and were the focus of this project.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014450
- Subject Headings
- Peripheral Nervous System Diseases, Chemotherapy, Caenorhabditis elegans, Cancer
- Format
- Document (PDF)
- Title
- Investigating a Cryptic Iron-Nitrogen Cycle in Lake Okeechobee Sediments`.
- Creator
- Silvera, Owen, Beckler, Jordon, Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
-
The overall objective was to elucidate the effect of iron (Fe) on nitrogen (N) diagenesis in Lake Okeechobee. Somewhat counterintuitively, sediment ammonium (NH+4) inventories decreased during algal growth as dissolved organic nitrogen (DON) inventories increased. Whole core incubations were staged for denitrification experiments using isotopic N tracer. Core incubations showed the percentage of sediment N removal increase between summer (25 ± 21 %) and winter (39 ± 13 %). The amendment of...
Show moreThe overall objective was to elucidate the effect of iron (Fe) on nitrogen (N) diagenesis in Lake Okeechobee. Somewhat counterintuitively, sediment ammonium (NH+4) inventories decreased during algal growth as dissolved organic nitrogen (DON) inventories increased. Whole core incubations were staged for denitrification experiments using isotopic N tracer. Core incubations showed the percentage of sediment N removal increase between summer (25 ± 21 %) and winter (39 ± 13 %). The amendment of Fe2+ enhanced this seasonal effect likely via dissimilatory nitrate reduction to ammonium (DNRA). The isotopic signature of N2 flux also suggested an additional, sedimentary, N2 source via Fe coupled anaerobic oxidation of ammonium (feammox). Sediment slurry incubations supported the occurrence of both DNRA and feammox, showing first that nitrate (NO3−) was converted to NH4+ via DNRA, which contributed 23-26% of overall NO3− reduction. Fe amendment in slurries similarly stimulated the feammox process. However, aged Fe minerals accumulated linearly with N bound to Fe (Fe-N) in a subseasonal sediment time series, suggesting Fe-organic matter aggregation may lower the sediment NH4+ equilibrium concentration and benthic flux.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014486
- Subject Headings
- Okeechobee, Lake (Fla.), Diagenesis, Sediments (Geology), Biogeochemistry
- Format
- Document (PDF)
- Title
- FLOOD RISK AND SOCIAL VULNERABILITY IN WALTON COUNTY, FL: AN INTEGRATED ASSESSMENT FOR URBAN RESILIENCE.
- Creator
- Sábio, Letícia, Mitsova, Diana, Florida Atlantic University, Department of Urban and Regional Planning, Charles E. Schmidt College of Science
- Abstract/Description
-
Walton County, Florida, a low-lying coastal region, is highly susceptible to flooding, sea level rise, and storm surges. These hazards disproportionately impact communities, with socially vulnerable populations being less likely to recover from disaster events. This study presents an integrated assessment of vulnerability to flooding, considering natural hazards such as a 1-day 100-year storm event, a 3-foot sea level rise scenario, and storm surge risk, combined with a social vulnerability...
Show moreWalton County, Florida, a low-lying coastal region, is highly susceptible to flooding, sea level rise, and storm surges. These hazards disproportionately impact communities, with socially vulnerable populations being less likely to recover from disaster events. This study presents an integrated assessment of vulnerability to flooding, considering natural hazards such as a 1-day 100-year storm event, a 3-foot sea level rise scenario, and storm surge risk, combined with a social vulnerability analysis, aiming to identify the most socially vulnerable communities within Walton County's flood-prone areas. Additionally, the integrated analysis takes into consideration a priority of land use approach, identifying facilities that are critical or essential for an emergency response and recovery. The study also recommends a series of projects, including green, gray, and hybrid solutions, as well as policy changes to mitigate flood risks and enhance resilience within these communities.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014478
- Subject Headings
- Urban planning, Walton County (Fla.), Floods--Risk assessment
- Format
- Document (PDF)
- Title
- FROM DNA TO GRAVITATIONAL WAVES: APPLICATIONS OF STATISTICS AND MACHINE LEARNING.
- Creator
- Alemrajabi, Mahsa Firouzabad, Tichy, Wolfgang, Assis, Raquel, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
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In the current world of fast-paced data production, statistics and machine learning tools are essential for interpreting and utilizing the full potential of this data. This dissertation comprises three studies employing statistical analysis and Convolutional Neural Network models. First, the research investigates the genetic evolution of the SARS-CoV-2 RNA molecule, emphasizing the role of epistasis in the RNA virus’s ability to adapt and survive. Through statistical tests, this study...
Show moreIn the current world of fast-paced data production, statistics and machine learning tools are essential for interpreting and utilizing the full potential of this data. This dissertation comprises three studies employing statistical analysis and Convolutional Neural Network models. First, the research investigates the genetic evolution of the SARS-CoV-2 RNA molecule, emphasizing the role of epistasis in the RNA virus’s ability to adapt and survive. Through statistical tests, this study validates the significant impacts of genetic interactions and mutations on the virus’s structural changes over time, offering insights into its evolutionary dynamics. Secondly, the dissertation explores medical diagnosis by implementing Convolutional Neural Networks to differentiate between lung CT-scans of COVID-19 and non-COVID patients. This portion of the research demonstrates the capability of deep learning to enhance diagnostic processes, thereby reducing time and increasing accuracy in clinical settings. Lastly, we delve into gravitational wave detection, an area of astrophysics requiring precise data analysis to identify signals from cosmic events such as black hole mergers. Our goal is to utilize Convolutional Neural Network models in hopes of improving the sensitivity and accuracy of detecting these difficult to catch signals, pushing the boundaries of what we can observe in the universe. The findings of this dissertation underscore the utility of combining statistical methods and machine learning models to solve problems that are not only varied but also highly impactful in their respective fields.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014454
- Subject Headings
- Neural networks (Computer science), Gravitational waves, Deep learning (Machine learning), Diagnosis, Epistasis, Genetic
- Format
- Document (PDF)
- Title
- Macbeth On Screen.
- Creator
- Oldfield, Pamela, Stockard, Emily, Florida Atlantic University, Department of English, Dorothy F. Schmidt College of Arts and Letters
- Abstract/Description
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It is the purpose of this thesis to analyze the fresh relevance of Shakespeare’s four-hundred-year-old tragedy Macbeth, as manifested in three contemporary films: Macbeth, directed by Rupert Goold, starring Patrick Stewart (2010); Macbeth, directed by Justin Kurzel, starring Michael Fassbender (2015); and The Tragedy of Macbeth, directed by Joel Coen, starring Denzel Washington (2021). The thesis examines the unique thematic ideas in each adaptation. The directors have distinct visions. Goold...
Show moreIt is the purpose of this thesis to analyze the fresh relevance of Shakespeare’s four-hundred-year-old tragedy Macbeth, as manifested in three contemporary films: Macbeth, directed by Rupert Goold, starring Patrick Stewart (2010); Macbeth, directed by Justin Kurzel, starring Michael Fassbender (2015); and The Tragedy of Macbeth, directed by Joel Coen, starring Denzel Washington (2021). The thesis examines the unique thematic ideas in each adaptation. The directors have distinct visions. Goold imagines Macbeth as a Stalinesque authoritarian. Kurzel’s Macbeth battles post-traumatic stress disorder. Coen’s older Macbeth is desperate to attain the status he is adamant he has earned, obsessed with the awareness that his time is limited to act. In these adaptations, underlying themes exploring the danger of the authoritarian personality, the heartbreaking futility of misplaced trust, the ravaging effects war may visit on the warrior’s psyche, and the dark places one may be led in the pursuit of ambition are presented to the audience for contemplation. The analysis draws from contemporary film criticism found in newspapers, magazines and scholarly journals. It is further supported by interviews with the directors and key actors, as well as autobiographical testimony. The elements used in the artistic craft of cinematography are explored. Recognizable references taken from earlier productions used by Joel Coen in his experimentation with Macbeth as a film noir are identified. Research which supports the relevance of the comparison of Macbeth to the historical Stalin is offered. Physicians’ clarification of the condition of PTSD enlightens the understanding of Kurzel’s interpretation.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014481
- Subject Headings
- Shakespeare, William, 1564-1616. Macbeth, Shakespeare, William, 1564-1616. Macbeth--Adaptations, Shakespeare, William, 1564-1616. Macbeth--Criticism and interpretation
- Format
- Document (PDF)
- Title
- NANOPARTICLE-INDUCED CATALYTIC CARBON CAPTURE: A MICROFLUIDICS APPROACH.
- Creator
- Donjuan, Joshua, Kim, Myeongsub, Florida Atlantic University, Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science
- Abstract/Description
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Due to technological advancement, energy consumption and demand have been increasing significantly, primarily satisfied by fossil fuel consumption. This reliance on fossil fuels results in substantial greenhouse gas emissions, with CO₂ being the most prominent contributor to global warming. To mitigate this issue and prevent CO₂ emissions, Carbon Capture, Utilization, and Storage (CCUS) technologies are employed. Among these, the amine scrubbing method is widely used due to its high CO2...
Show moreDue to technological advancement, energy consumption and demand have been increasing significantly, primarily satisfied by fossil fuel consumption. This reliance on fossil fuels results in substantial greenhouse gas emissions, with CO₂ being the most prominent contributor to global warming. To mitigate this issue and prevent CO₂ emissions, Carbon Capture, Utilization, and Storage (CCUS) technologies are employed. Among these, the amine scrubbing method is widely used due to its high CO2 capture efficiency and regenerative ability. However, this method has drawbacks, including high toxicity, corrosion, and substantial freshwater consumption. To develop an environmentally sustainable carbon capture solution, researchers are exploring alternatives such as the use of seawater and enhanced CO2 capture with catalysts. In this study, we analyze the catalytic performance of nickel nanoparticles (NiNPs) in seawater with carboxymethyl cellulose (CMC) polymers. Using flow-focusing geometry-based microfluidic channels, we investigated CO₂ dissolution at various concentrations of nanoparticles and CMC polymers. The objective is to optimize the concentration of nanoparticles and CMC polymers for effective CO₂ dissolution. We utilized NiNPs with diameters of 100 nm and 300 nm in CMC concentrations of 100 ml/L, 200 ml/L, and 300 ml/L. Additionally, NiNP concentrations ranging from 6 mg/L to 150 mg/L were tested for CO₂ dissolution in seawater. The results indicated that a concentration of 10 mg/L NiNPs in 100 mg/L CMC provided a CO₂ dissolution of 57%, the highest for this specific CMC concentration. At CMC concentrations of 200 ml/L and 300 ml/L, NiNP concentrations of 70 mg/L and 90 mg/L achieved CO₂ dissolution rates of 58.8% and 67.2%, respectively.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014483
- Subject Headings
- Carbon sequestration, Global warming, Polymer chemistry, Nanoparticles
- Format
- Document (PDF)
- Title
- IMPACTS OF ROTATIONAL IMPOUNDMENT MANAGEMENT (RIM) AND SUMMER DRAWDOWNS ON THE MIGRATIONS OF JUVENILE FISHES IN INDIAN RIVER LAGOON MOSQUITO CONTROL IMPOUNDMENTS.
- Creator
- Reinhard, Rachel, McCoy, Michael, Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
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Impoundments in the Indian River Lagoon, originally built to control saltmarsh mosquitoes, led to the isolation of fish nursery habitats. Rotational Impoundment Management (RIM) aims to mitigate this by hydrologically reconnecting impoundments during mosquito non-breeding seasons. However, current practices may not effectively facilitate juvenile fish emigration. This study incorporates summer openings (drawdowns) of culverts into RIM to improve the emigration of juvenile tarpon and snook....
Show moreImpoundments in the Indian River Lagoon, originally built to control saltmarsh mosquitoes, led to the isolation of fish nursery habitats. Rotational Impoundment Management (RIM) aims to mitigate this by hydrologically reconnecting impoundments during mosquito non-breeding seasons. However, current practices may not effectively facilitate juvenile fish emigration. This study incorporates summer openings (drawdowns) of culverts into RIM to improve the emigration of juvenile tarpon and snook. Tagged fish were monitored with RFID technology for 18 months in four impoundments. The abundance and size distribution of tarpon and snook populations differed among impoundments, reflecting variations in habitat structure and water quality. Summer drawdowns did not significantly increase emigration rates. However, tarpon detections increased during closed-culvert periods in all impoundments, and snook detections increased in one impoundment. Despite low emigrations, the study offers insight into the behavior of juvenile fish in these impoundments and suggests ways to enhance their nursery functionality.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014468
- Subject Headings
- Surface impoundments, Indian River (Fla. : Lagoon), Fisheries, Aquatic sciences
- Format
- Document (PDF)
- Title
- AN ASSESSMENT OF WATER-RELATED VULNERABILITY FOR DEVELOPED PROPERTIES IN COASTAL FORT LAUDERDALE.
- Creator
- Salazar, Stephanya Lotero, Bloetscher, Frederick, Florida Atlantic University, Department of Civil, Environmental and Geomatics Engineering, College of Engineering and Computer Science
- Abstract/Description
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Flooding disasters pose a significant threat worldwide, with 2022 seeing them as the most common type of disaster. In the U.S. alone, four flooding disasters in 2023 cost more than $9.2 billion. Coastal urban areas face increasing threats from flooding disasters due to rising sea levels, changing precipitation patterns, and intensifying extreme weather events. This study focuses on Central Beach, Fort Lauderdale; the area's unique geographical, environmental, historical, and socio-economic...
Show moreFlooding disasters pose a significant threat worldwide, with 2022 seeing them as the most common type of disaster. In the U.S. alone, four flooding disasters in 2023 cost more than $9.2 billion. Coastal urban areas face increasing threats from flooding disasters due to rising sea levels, changing precipitation patterns, and intensifying extreme weather events. This study focuses on Central Beach, Fort Lauderdale; the area's unique geographical, environmental, historical, and socio-economic characteristics make it a prime candidate for this analysis. The research objective is to comprehensively examine the factors contributing to water-related vulnerabilities of developed properties in Central Beach and assess localized impacts using regional models. The methodology involves developing probabilistic flood maps using GIS tools and the Cascade 2001 routing model. The flood scenarios consider groundwater table rise, extreme rainfall, high tides, storm surge, and sea level rise. Results indicate significant inundation risks, particularly for commercial and mobility infrastructure, under storm surge and sea level rise scenarios. The analysis highlights the importance of targeted mitigation efforts to protect these areas and reinforce resilience against future flooding events. The findings contribute valuable insights for policymakers, urban planners, and stakeholders, emphasizing the need for comprehensive strategies to mitigate flood risks in coastal urban areas.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014484
- Subject Headings
- Floods, Fort Lauderdale (Fla.), Urban planning
- Format
- Document (PDF)
