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Pages
- Title
- SUPRESSING IGF-R1 SIGNALING PATHWAY RESCUES NEURONAL OVERGROWTH OF PTEN +/- MICE.
- Creator
- Laffita, Dalina, Earles, Julie L., Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
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Macrocephaly is a well-replicated phenotype in a subset of individuals with autism spectrum disorder (ASD). Heterozygous mutation in PTEN, which encode a negative regulator of the PI3K-mTR signaling pathway, causes the macrocephaly/autism syndrome. Mice with germline heterozygous Pten deletion (Pten+/-) exhibit both brain overgrowth and social behavioral deficits. Here, we showed that reduction of Igf-1 receptor (Igf-1r), which is an upstream receptor of PI3K-mTOR pathway, in Pten+/- mice...
Show moreMacrocephaly is a well-replicated phenotype in a subset of individuals with autism spectrum disorder (ASD). Heterozygous mutation in PTEN, which encode a negative regulator of the PI3K-mTR signaling pathway, causes the macrocephaly/autism syndrome. Mice with germline heterozygous Pten deletion (Pten+/-) exhibit both brain overgrowth and social behavioral deficits. Here, we showed that reduction of Igf-1 receptor (Igf-1r), which is an upstream receptor of PI3K-mTOR pathway, in Pten+/- mice rescues the neuronal overgrowth of cortical layer V neurons, which is associated with social behavior deficits shown in the Pten+/- mice. These are promising results shows that a pharmacological agent, one that blocks Igf1r, could recover the damage done by the Pten mutation. However, the pathway being targeted is a cellular pathway within the brain and any potential pharmacological agent must be able to cross the blood brain barrier, and must alter the pathway within the brain and not influence other pathways within the system.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00026
- Format
- Document (PDF)
- Title
- FALSE MEMORIES AND WHAT CONTRIBUTES TO THEIR FORMATION.
- Creator
- Braga, Milena Da Silva, Earles, Julie L., Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
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This study sought to understand the influences of familiarity on the formation of false memories. Participants watched videos of actors performing actions, and were either asked to remember specific pairings of actor and action, or just the actor. Recognition was assessed through watching videos containing the same actor/action pairing, new actors, new actions, and familiar actors/actions that weren’t originally paired (conjunction). Other participants heard actors saying phrases instead (eg....
Show moreThis study sought to understand the influences of familiarity on the formation of false memories. Participants watched videos of actors performing actions, and were either asked to remember specific pairings of actor and action, or just the actor. Recognition was assessed through watching videos containing the same actor/action pairing, new actors, new actions, and familiar actors/actions that weren’t originally paired (conjunction). Other participants heard actors saying phrases instead (eg. waving a flag versus saying “wave the flag”). There was a significant difference between actions and phrases in incorrect “yes” responses to new actors (t(94)=-2.244, p<.05) and incorrect “yes” responses to new actions (t(94)=-3.901, p<.05). Participants were more likely to misidentify a phrase than they were an action. There was also a significant difference between incorrect “yes” responses to conjunction videos and new actor/action/phrase conditions, suggesting that the presence of two familiar stimuli facilitate the formation of a false memory.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00074
- Format
- Document (PDF)
- Title
- An animal model of performance enhancing drugs and catastrophic interference.
- Creator
- Rabinowitz, Akiva, Earles, Julie L., Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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The neural networks that underlie memory and learning are some of the most complex systems that scientists seek to describe. Recent research has demonstrated that drugs which increase synaptic plasticity possess the capacity to enhance memory. The question that the present study sought to address was whether it is possible that cognition-enhancing drugs might enhance some memories to the detriment of others. Mice of the C57BL/6J inbred strain were trained on the Morris water maze task. They...
Show moreThe neural networks that underlie memory and learning are some of the most complex systems that scientists seek to describe. Recent research has demonstrated that drugs which increase synaptic plasticity possess the capacity to enhance memory. The question that the present study sought to address was whether it is possible that cognition-enhancing drugs might enhance some memories to the detriment of others. Mice of the C57BL/6J inbred strain were trained on the Morris water maze task. They were then transferred over to a second, similar, water maze and trained using either the cognition-enhancing drug apamin or saline injected intraperitoneally. A strong correlation was observed in the apamin mice. The better they learned the second water maze task, the poorer they recalled the solution to the initial water maze. Our findings support the concept that performance-enhancing drugs are a facilitative factor in the memory phenomenon of proactive interference.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00003600
- Format
- Document (PDF)
- Title
- The death of privacy: an empirical analysis of fourth amendment jurisprudence.
- Creator
- Mathieu, Wesley, Tunick, Mark, Earles, Julie, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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Privacy as a legal concept affects every single American citizen whether they know it or not. Justice Harlan's concurrence in Katz v. United States, 389 U.S. 347 defined an expectation of privacy as one that society must recognize as objectively reasonable. The court has used this doctrine to establish different privacy tests for different situations, yet has never empirically determined whether its decisions accurately reflect society's view of what is 'reasonable.' To that end, this paper...
Show morePrivacy as a legal concept affects every single American citizen whether they know it or not. Justice Harlan's concurrence in Katz v. United States, 389 U.S. 347 defined an expectation of privacy as one that society must recognize as objectively reasonable. The court has used this doctrine to establish different privacy tests for different situations, yet has never empirically determined whether its decisions accurately reflect society's view of what is 'reasonable.' To that end, this paper will examine the philosophical and historical origins of the right to privacy, and well as its development by the Supreme Court to its current status. I'll compare the Supreme Court's interpretation of society's expectations with empirical data from psychological studies and conduct a normative analysis to determine if the Supreme Court has accurately interpreted society's expectations and correctly crafted the right to privacy to ideally protect the citizens and limit state invasions of privacy.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00003593
- Format
- Document (PDF)
- Title
- Neurofeedback Training Therapy: The Future of Treatment Options for Alzheimer’s Disease.
- Creator
- Payne, Alyssa Maria, Earles, Julie, Harriet L. Wilkes Honors College, Florida Atlantic University, Vernon, Laura
- Abstract/Description
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This exploratory investigation seeks to evaluate the efficacy of Neurofeedback (NFB) Training Therapy, a type of biofeedback that works with the brain’s natural capacity for plasticity, as a viable treatment for patients with Alzheimer’s Disease (AD). Strengthening connections among remaining neurons despite neurogenesis may benefit patients. However, the vast array of methodologies utilizing different technologies and focusing on varying brain waves makes it challenging to determine the true...
Show moreThis exploratory investigation seeks to evaluate the efficacy of Neurofeedback (NFB) Training Therapy, a type of biofeedback that works with the brain’s natural capacity for plasticity, as a viable treatment for patients with Alzheimer’s Disease (AD). Strengthening connections among remaining neurons despite neurogenesis may benefit patients. However, the vast array of methodologies utilizing different technologies and focusing on varying brain waves makes it challenging to determine the true efficacy of the treatment methods, especially when compounded with the number of disorders each method is claimed to treat. Therefore, this investigation aims to address 1) technology that will best target specific brain areas, and 2) the most suitable NBF protocols for patients with AD. Taken together, this analysis contributes towards assessing the feasibility of NFB as treatment for patients with dementia, leading to the determination that electroencephalography (EEG) NFB with peak alpha or theta brainwave protocols may be the best option.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00154
- Format
- Document (PDF)
- Title
- Portrayals of Autism Spectrum Disorder in Contemporary Fiction.
- Creator
- Boerth-Dryden, Lara, Earles, Julie, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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Literature is an integral medium through which individuals use language to create a shared experience with an audience. Writing as an act is an intimate expression of identity. So, what does it mean that there are some voices who are not equally represented and heard in literature? There is an interesting juxtaposition between literature and disabilities. Certain people with disabilities such as Autism Spectrum Disorder (ASD) struggle at communication, articulation, and interpretation. This...
Show moreLiterature is an integral medium through which individuals use language to create a shared experience with an audience. Writing as an act is an intimate expression of identity. So, what does it mean that there are some voices who are not equally represented and heard in literature? There is an interesting juxtaposition between literature and disabilities. Certain people with disabilities such as Autism Spectrum Disorder (ASD) struggle at communication, articulation, and interpretation. This paper seeks to analyze representations and portrayals of individuals with ASD in fiction, and compare differences in these representations based on whether the author has an ASD diagnosis. The authors who have received a diagnosis of ASD do portray a more nuanced understanding of ASD in day to day life; however, the authors who lack a diagnosis still represented character’s with ASD in an accurate light.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00246
- Format
- Document (PDF)
