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Title: Organotin Polyethers as Biomaterials.
Creator: Carraher, Charles E., Roner, Michael R.
Abstract/Description: Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of...
Show moreOrganotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synthetic diols. Included in these materials are the first water soluble organotin polymers. The organotin polyethers exhibit a wide range of biological activities. Some selectively inhibit a number of unwanted bacteria, including Staph. MRSA, and unwanted yeasts such as Candida albicans. Some also inhibit a variety of viruses including those responsible for herpes infections and smallpox. Others show good inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer. The synthesis, structural characterization, and biological characterization of these materials is described in this review.
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Date Issued: 2009-10-21
PURL: http://purl.flvc.org/fau/fd/FAUIR000010
Format: Citation

Title: Materials and methods for controlling methicillin-resistant Staphylococcus aureus microbes.
Creator: Carraher, Charles E., Butler, Cynthia, Florida Atlantic University
Date Issued: 1998-11
PURL: http://purl.flvc.org/fcla/dt/15842
Format: Document (PDF)

Title: Novel compunds for the control of microorganisms.
Creator: Carraher, Charles E., Butler, Cynthia, Florida Atlantic University
Date Issued: 1991-08
PURL: http://purl.flvc.org/fcla/dt/15859
Format: Document (PDF)

Title: Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro.
Creator: Carraher, Charles E., Roner, Michael R., Shahi, Kimberly, Barot, Girish
Abstract/Description: The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much...
Show moreThe ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
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Date Issued: 2011-04-15
PURL: http://purl.flvc.org/fau/fd/FAUIR000009
Format: Citation

Title: Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers.
Creator: Roner, Michael R., Carraher, Charles E., Shahi, Kimberly, Barot, Girish
Abstract/Description: Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will...
Show morePolymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.
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Date Issued: 2011-05-27
PURL: http://purl.flvc.org/fau/fd/FAUIR000008
Format: Citation

Title: Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines.
Creator: Roner, Michael R., Carraher, Charles E., Shahi, Kimberly, Ashida, Yuki, Barot, Girish
Date Issued: 2009-10-07
PURL: http://purl.flvc.org/fcla/dt/3325102
Format: Document (PDF)

Title: Synthesis and characterization of group IVB metallocene materials derived from hematoporphyrin IX.
Creator: Rivalta, Alberto Enrico., Florida Atlantic University, Carraher, Charles E., Haky, Jerome E.
Abstract/Description: New organometallic containing materials were synthesized by the reaction of Group IVB metallocene dichlorides of the form Cp2MCl2 where M = Ti, Ar, and Hf with Hematoporphyrin IX using the interfacial condensation polymerization technique. The structural characterization was accomplished using infrared and mass spectroscopy and elemental analysis. The results obtained from these techniques showed the presence of the metal ester and ether bonding as evidence that the reaction occurred. The...
Show moreNew organometallic containing materials were synthesized by the reaction of Group IVB metallocene dichlorides of the form Cp2MCl2 where M = Ti, Ar, and Hf with Hematoporphyrin IX using the interfacial condensation polymerization technique. The structural characterization was accomplished using infrared and mass spectroscopy and elemental analysis. The results obtained from these techniques showed the presence of the metal ester and ether bonding as evidence that the reaction occurred. The product derived from titanocene dichloride, 12-A, exhibited growth inhibition characteristics towards the Candid albicans and Staphylococcus aureus microorganisms. From the preliminary metal adsorption studies it was shown that this product also bound nickel ions.
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Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14940
Subject Headings: Organometallic chemistry, Porphyrins, Hematoporphyrin, Metallocenes
Format: Document (PDF)

Title: I. The synthesis of organotin-modified poly(vinyl alcohol) for the inhibition of Candida albicans. II. The synthesis and structural characterization of titanocene-containing polyethers based on ethylene glycols.
Creator: Reckleben, Lisa., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Organotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the...
Show moreOrganotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the microorganism most responsible for yeast infections in man. The titanocene-containing polyethers exhibited flexibility when derived from longer chained polyethylene glycols, but were inflexible when shorter chained polyethylene glycols were used.
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Date Issued: 1991
PURL: http://purl.flvc.org/fcla/dt/14752
Subject Headings: Candida albicans, Organometallic polymers, Polymerization, Polyethylene glycol
Format: Document (PDF)

Title: Synthesis of polyphosphate esters from pentaerythritol ester of phosphorochloridic acid and diols.
Creator: Deng, Guoping., Florida Atlantic University, Parkanyi, Cyril, Carraher, Charles E.
Abstract/Description: Polyphosphate esters have been synthesized from reaction of the pentaerythritol ester of phosphorochloridic acid with different diols--bisphenol A, 1,6-hexanediol, 1,3-bis(4-hydroxybutyl)-tetramethyldisiloxane and 5-iodo-2'-deoxyuridine. All products are medium to high molecular weight. The product from bisphenol A gives fibers from concentrated solution. The product from 1,3-bis(4-hydroxybutyl)-tetramethyldisiloxane acts as an adhesive. The products were made for potential flame retardant...
Show morePolyphosphate esters have been synthesized from reaction of the pentaerythritol ester of phosphorochloridic acid with different diols--bisphenol A, 1,6-hexanediol, 1,3-bis(4-hydroxybutyl)-tetramethyldisiloxane and 5-iodo-2'-deoxyuridine. All products are medium to high molecular weight. The product from bisphenol A gives fibers from concentrated solution. The product from 1,3-bis(4-hydroxybutyl)-tetramethyldisiloxane acts as an adhesive. The products were made for potential flame retardant applications in the electronics industry. The characterizations by MS, NMR and FT-IR are in agreement with the proposed structures.
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Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15275
Subject Headings: Polyphosphates, Phosphorus compounds, Polymerization, Inorganic fibers, Fire resistant polymers
Format: Document (PDF)

Title: Synthesis and structural characterization of vanadocene containing polymers.
Creator: Randolph, Ernest B., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: The synthesis of polymers which contain vanadocene in the polymer backbone is accomplished by interfacial condensation reactions with the appropriate diols, diacids, and diamines. Structural characterization is accomplished by using FTIR and HREI-MS spectroscopic methods. Weight average molecular weights were determined using light scattering photometry for products which are soluble. Molecular weights for the products vary from 3500 to 15,000 Daltons. The structural characterization results...
Show moreThe synthesis of polymers which contain vanadocene in the polymer backbone is accomplished by interfacial condensation reactions with the appropriate diols, diacids, and diamines. Structural characterization is accomplished by using FTIR and HREI-MS spectroscopic methods. Weight average molecular weights were determined using light scattering photometry for products which are soluble. Molecular weights for the products vary from 3500 to 15,000 Daltons. The structural characterization results are consistent with the proposed structures.
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Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15299
Subject Headings: Polymers, Polymerization, Vanadium
Format: Document (PDF)

Title: The effects of the chelating agents on the 123-superconductor.
Creator: Zhuang, Huifang, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: This study reports the initial evaluation of the effect of selected chelating agents on the 123-superconductor. For the chelating agents oxalic acid and disodium oxalate, the extent and the rate of magnetic susceptibility decrease are discussed with respect to their concentration, site of chelation, exposure time and selectivity. The magnetic susceptibility measurements were carried out with a Superconductor Characterization Cryostat and the surface analysis was accomplished by employing...
Show moreThis study reports the initial evaluation of the effect of selected chelating agents on the 123-superconductor. For the chelating agents oxalic acid and disodium oxalate, the extent and the rate of magnetic susceptibility decrease are discussed with respect to their concentration, site of chelation, exposure time and selectivity. The magnetic susceptibility measurements were carried out with a Superconductor Characterization Cryostat and the surface analysis was accomplished by employing Auger Electron Spectroscopy (AES) and X-Ray Photoelectron Spectroscopy (XPS). The results show that the solution containing oxalic acid can remove copper atoms from the superconductor surface. The extent and the rate of superconductivity decrease can be controlled by changes in concentration, addition sequence and exposure time.
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Date Issued: 1990
PURL: http://purl.flvc.org/fcla/dt/14627
Subject Headings: High temperature superconductors, Chelates
Format: Document (PDF)

Title: FTIR Diffuse Reflectance Quantitative Analysis of Nitric Acid Oxidation of Paraffin Oil Supported on a Polytetrafluoroethylene (PTFE) Substrate.
Creator: Smith, Larry, Carraher, Charles E., Florida Atlantic University
Abstract/Description: Nitric acid can drive oxidation reactions of paraffins producing nitroparaffins and other oxidation products. Presented here is a study on the aqueous liquid phase nitric acid oxidation of paraffin oil supported on PTFE particles. The goals ofthis study are: 1. To evaluate the effectiveness of nitric acid in removing paraffin oil from PTFE particle surfaces. 2. To evaluate the effects of nitric acid driven reactions with paraffin oils under varying reaction conditions. 3. To evaluate FTIR...
Show moreNitric acid can drive oxidation reactions of paraffins producing nitroparaffins and other oxidation products. Presented here is a study on the aqueous liquid phase nitric acid oxidation of paraffin oil supported on PTFE particles. The goals ofthis study are: 1. To evaluate the effectiveness of nitric acid in removing paraffin oil from PTFE particle surfaces. 2. To evaluate the effects of nitric acid driven reactions with paraffin oils under varying reaction conditions. 3. To evaluate FTIR Diffuse Reflectance Spectroscopy, DRIFT, as a tool to accomplish the quantitative analysis of this process. These goals have been achieved employing analysis by FTIR Diffuse Reflectance, which provides a ready means of quantifying paraffin removal. Paraffin removal generally increases with time, temperature and nitric acid concentration and can be described by known kinetics including activation energy and region of unity relationship between the log of the rate constant verses Hammett acidity function.
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Date Issued: 2007
PURL: http://purl.flvc.org/fau/fd/FA00000831
Subject Headings: Free radicals (Chemistry), Reflectance spectroscopy, Chemistry, Analytic--Quantitative, Oxidation
Format: Document (PDF)

Title: Synthesis and characterization of ruthenium-containing polymers.
Creator: Zhang, Qingmao, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Ruthenium-containing polymers derived from dichloro-bis(2,2-bipyridine)-ruthenium and selected dithiol or diamines have been synthesized. These polymeric products were characterized using FTIR, ultraviolet spectroscopy, light scattering photometry and mass spectral analysis. Thermal degradation studies of these products are presented.
Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14952
Subject Headings: Ruthenium compounds, Ligands, Organometallic polymers, Mass spectrometry
Format: Document (PDF)

Title: Synthesis and characterization of poly(magnesium acrylate) and poly(zirconyl acrylate) towards formation of magnesia partially stabilized zirconia ceramics.
Creator: Xu, Xinhua, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Poly(magnesium acrylate) and poly(zirconyl acrylate) have been formed by chelating the magnesium ion and the zirconyl ion onto poly(acrylic acid). The PAA is usually neutralized by addition of sodium hydroxide before the synthesis process. The structures and characterisitics of these polymers are studied by various analytical methods such as thermal analysis, elemental analysis, infrared spectroscopy, and mass spectroscopy. The formation of these polymers is verified and their structures are...
Show morePoly(magnesium acrylate) and poly(zirconyl acrylate) have been formed by chelating the magnesium ion and the zirconyl ion onto poly(acrylic acid). The PAA is usually neutralized by addition of sodium hydroxide before the synthesis process. The structures and characterisitics of these polymers are studied by various analytical methods such as thermal analysis, elemental analysis, infrared spectroscopy, and mass spectroscopy. The formation of these polymers is verified and their structures are determined. In addition, a preliminary attempt was carried out to make an advanced structural ceramic from a mixture of poly(magnesium acrylate) and poly(zirconyl acrylate).
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Date Issued: 1997
PURL: http://purl.flvc.org/fcla/dt/15367
Subject Headings: Polymers, Ceramics
Format: Document (PDF)

Title: Synthesis and characterization of organostannane modified poly(ethylene-co-vinyl alcohol) copolymers.
Creator: Pandya, Bhoomin Mahendra., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Ethylene/vinyl alcohol (EVOH) copolymers are widely used. These copolymers have been reacted with metallic and organometallic groups for various applications. In the present work, organostannane modified EVOH copolymers are synthesized and characterized and their structure-property relationships, especially with respect to their applications as antibacterials and fungicides as well as their film forming ability, are studied. The modified copolymers exhibit "ionomer-like" thermal properties....
Show moreEthylene/vinyl alcohol (EVOH) copolymers are widely used. These copolymers have been reacted with metallic and organometallic groups for various applications. In the present work, organostannane modified EVOH copolymers are synthesized and characterized and their structure-property relationships, especially with respect to their applications as antibacterials and fungicides as well as their film forming ability, are studied. The modified copolymers exhibit "ionomer-like" thermal properties. Some of the properties of the modified EVOH products are also compared to analogous modified polyvinyl alcohol products.
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Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14939
Subject Headings: Organotin compounds, Ionomers, Ethylene compounds
Format: Document (PDF)

Title: Synthesis and characterization of ruthenium-containing polymers derived from diamine-containing dyes.
Creator: Murphy, Amanda Taylor, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Ruthenium-containing polymers derived from cis-dichloro-bis(2-2'-bipyridine) ruthenium and selected diamine-containing dyes have been synthesized. These polymeric products were characterized using FTIR, UV-Vis spectroscopy, light scattering photometry, and mass spectral analysis. Thermal degradation studies of these products are also presented.
Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15244
Subject Headings: Polymers, Ruthenium compounds, Photochemistry, Dyes and dyeing--Chemistry, Solar energy
Format: Document (PDF)

Title: Synthesis and structural characterization of organometallic tin-containing ionomers based on a copolymer of ethylene and acrylic acid.
Creator: He, Fengchen, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Tin-containing ionomers were synthesized by reaction of poly(ethylene/acrylic acid) with mono, di and trihalo-organostannanes using the interfacial condensation technique. The products contain tin ester bonding as evidenced by infrared and mass spectroscopy. They are insoluble but form tough transparent films on application of heat and pressure. The modified ionomer products were flexible with high degrees of substitution and contained both bridging and nonbridging structures with respect to...
Show moreTin-containing ionomers were synthesized by reaction of poly(ethylene/acrylic acid) with mono, di and trihalo-organostannanes using the interfacial condensation technique. The products contain tin ester bonding as evidenced by infrared and mass spectroscopy. They are insoluble but form tough transparent films on application of heat and pressure. The modified ionomer products were flexible with high degrees of substitution and contained both bridging and nonbridging structures with respect to bonding about the tin atom. The analogous products from poly(acrylic acid) were brittle with lower substitutions and contained on nonbridging structure.
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Date Issued: 1992
PURL: http://purl.flvc.org/fcla/dt/14830
Subject Headings: Ionomers, Organotin compounds
Format: Document (PDF)

Title: Synthesis and structural characterization of organotin and group IVB metallocene dichlorides with kinetin.
Creator: Chamely-Wiik, Donna M., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Metal containing polymers were synthesized by reaction of organotin and group IVB metallocene dichlorides with kinetin, a plant growth hormone (PGH), via the interfacial polycondensation process. Product yields were in the range of 40--63% and degrees of polymerization were from 20 to 150. The structures of the products were determined using infrared and mass spectroscopy. Further characterization involved determination of solubility, degree of polymerization and electrical conductivity. The...
Show moreMetal containing polymers were synthesized by reaction of organotin and group IVB metallocene dichlorides with kinetin, a plant growth hormone (PGH), via the interfacial polycondensation process. Product yields were in the range of 40--63% and degrees of polymerization were from 20 to 150. The structures of the products were determined using infrared and mass spectroscopy. Further characterization involved determination of solubility, degree of polymerization and electrical conductivity. The biological potential of the products was tested against selected microorganisms and Balb/3T3 cell lines. One of the products showed activity in the 0.2mug/ml range, one hundredth of that of similar compounds. Germination experiments using the PGH incorporated polymers were performed on sawgrass and cattail seeds as well as selected vegetable seeds and compared to a control. Sawgrass germination, typically in the 0--2% range were increased to about 60% through the treatment with kinetin-containing polymers.
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Date Issued: 2000
PURL: http://purl.flvc.org/fcla/dt/12675
Subject Headings: Polymeric composites, Organotin compounds, Plant hormones
Format: Document (PDF)

Title: The synthesis of chitosan-cis-DDP derivative.
Creator: Francis, Ann-Marie, Florida Atlantic University, Louda, Deborah W., Carraher, Charles E.
Abstract/Description: The formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity...
Show moreThe formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity of cis-DDP but produce fewer toxic side effects. Structural characterization involved infrared spectroscopy, mass spectroscopy, EDAX analytical methods. Products were also analyzed using light scattering photometry, elemental analysis and solubility studies. Additionally, the biological activity of water-soluble products was tested against selected cell lines.
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Date Issued: 1999
PURL: http://purl.flvc.org/fcla/dt/15699
Subject Headings: Chitosan, Polymeric drugs
Format: Document (PDF)

Title: Synthesis and structural characterization of intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease.
Creator: Chamely-Wiik, Donna M., Florida Atlantic University, Haky, Jerome E., Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: We have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that...
Show moreWe have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that had a unique set of characteristics. Upon reduction of the N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-benzyloxyphenyl)-L-alanine benzylester, which contained a ketone moiety, to produce the secondary alcohol, we discovered that the materials that were formed included a pair of diastereomers of the secondary alcohol, each diastereomer also exhibiting two individually stable conformational isomers. We believe that the conformational isomers were generated by rotation of the C-N bond of the BOC carbamate, and were so stable that they could be separated by HPLC and NMR techniques. Energy optimization studies and molecular modeling techniques were performed using HyperChem, and rotational barrier energy values were calculated for the different conformational isomers for each of the diastereomers. HPLC and NMR techniques were also used to obtain information about these materials. Using the calculated data from these studies, and analyzing the HPLC chromatograms and NMR spectra we were able to fully determine the assignments for the diastereomers and the individual conformational isomers. We discovered that the SS form was synthesized preferentially over the SR form and that in both cases the E conformation was energetically more stable than the Z form. Octanol/water partition coefficient values (Log P0ct) were also determined and compared to L-dopa and dopamine. We concluded that the values for the dimeric compound that we synthesized and many of its potential products of degradation were significantly higher than that for both L-dopa and dopamine. This may be an indication that this material has a higher degree of lipophilicity than L-dopa itself, having more potential to cross the blood brain barrier. We believe that these intermediate materials serve as good indication of how a polyphosphonate ester containing L-dopa would compare as a potential drug for Parkinson's disease.
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Date Issued: 2004
PURL: http://purl.flvc.org/fcla/dt/12108
Subject Headings: Parkinson's disease--Treatment, Antiparkinsonian agents, Dopa, Organophosphorus compounds--Synthesis, Chemistry, Analytic
Format: Document (PDF)

FAU Theses and Dissertations (19)	+ -
FAU College Collections (4)	+ -
Florida Atlantic University Patents (2)	+ -
Citation Records (1)	+ -

Organometallic polymers (6)	+ -
Organotin compounds (4)	+ -
Metallocenes (3)	+ -
Polymerization (3)	+ -
Polymers (3)	+ -

Ionomers (2)	+ -
Ligands (2)	+ -
Ruthenium compounds (2)	+ -
Antineoplastic agents--Development (1)	+ -
Antiparkinsonian agents (1)	+ -
Azo compounds (1)	+ -
Candida albicans (1)	+ -
Ceramics (1)	+ -
Chelates (1)	+ -
Chemistry, Analytic (1)	+ -
Chemistry, Analytic--Quantitative (1)	+ -
Chitosan (1)	+ -
Dopa (1)	+ -
Dyes and dyeing--Chemistry (1)	+ -
Ethylene compounds (1)	+ -
Fire resistant polymers (1)	+ -
Free radicals (Chemistry) (1)	+ -
Glycylglycine (1)	+ -
Hematoporphyrin (1)	+ -
High temperature superconductors (1)	+ -
Infrared spectroscopy (1)	+ -
Inorganic fibers (1)	+ -
Mass spectrometry (1)	+ -
Nuclear magnetic resonance (1)	+ -
Organometallic chemistry (1)	+ -

Electronic Thesis or Dissertation (19)	+ -
article (4)	+ -
patent (2)	+ -

Carraher, Charles E. (26)	+ -
Florida Atlantic University (21)	+ -
Charles E. Schmidt College of Science (6)	+ -
Department of Chemistry and Biochemistry (6)	+ -
Haky, Jerome E. (4)	+ -

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