Current Search: Blanks, Janet C. (x) » Neovascularization (x)
-
-
Title
-
Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity.
-
Creator
-
Solomon, Evertz Stenson, Blanks, Janet C., Florida Atlantic University
-
Abstract/Description
-
Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy. We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina....
Show moreOcular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy. We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina. The mouse ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen for five days, then were given intraocular injection of IL-100 and NV was evaluated after seven days in room air. Controls were uninjected contralateral eyes. IL-l 0 strongly inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and possibly, in AMD where inflammation is a risk factor.
Show less
-
Date Issued
-
2007
-
PURL
-
http://purl.flvc.org/fau/fd/FA00000833
-
Subject Headings
-
Neovascularization, Neovascularization inhibitors, Interleukin-10
-
Format
-
Document (PDF)
