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Nuclear magnetic resonance spectroscopic studies of metallocene (IVB) squarate polymers and other metallocene (IVB)-containing polymers
Title
Nuclear magnetic resonance spectroscopic studies of metallocene (IVB) squarate polymers and other metallocene (IVB)-containing polymers.
Creator
Li, Alicia Qing, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Group IVB metallocene polymers and oligomers undergo a pi-sigma rearrangement of the cyclopentadienyl moieties in DMSO based on NMR data. The sigma-Cp rings are stereochemically rigid at room temperature.
Date Issued
1991
PURL
http://purl.flvc.org/fcla/dt/14681
Subject Headings
Organometallic polymers, Metallocenes, Nuclear magnetic resonance
Format
Document (PDF)
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine
Title
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine.
Creator
Slawek, Paul Peter, Carraher, Charles E., Haky, Jerome E., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
This research is part of a long-term project aimed at elucidating important structural features, of both ligands and metals, that are needed to produce effective anti-cancer agents. The specific goal is the synthesis of organotin polymers containing amino acids, in this case the diamino acid diglycine. The desired materials were synthesized with percent yields ranging from 32-99%. The products were synthesized employing the interfacial polymerization technique. The polymers were then...
Show moreThis research is part of a long-term project aimed at elucidating important structural features, of both ligands and metals, that are needed to produce effective anti-cancer agents. The specific goal is the synthesis of organotin polymers containing amino acids, in this case the diamino acid diglycine. The desired materials were synthesized with percent yields ranging from 32-99%. The products were synthesized employing the interfacial polymerization technique. The polymers were then characterized utilizing the following physical characterization techniques: light scattering photometry (LS), Infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and matrix assisted laser desorption mass spectroscopy (MALDI). Physical characterization showed evidence of formation of desired adducts in addition to data that was consistent with the formation of materials containing multiple repeat units. The materials were then analyzed for biological activity. The synthesized materials displayed the ability to inhibit tested cancer cell lines.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00013158
Subject Headings
Organotin Compounds, Glycylglycine, Antineoplastic agents--Development
Format
Document (PDF)
Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives
Title
Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives.
Creator
Kloss, John Edward, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Reaction of Group IVB metallocene dichlorides with a monoaza dye yields a polymer in which the metal is bonded to a sulfonic and a hydroxyl group. The structure and bonding of the polymer was confirmed using infrared, mass spectrometry and 1H-NMR spectroscopy. Thermo and elemental analysis was used to confirm the presence of the metal. The stability of the polydye to the monomer unit was compared employing an argon laser in the visible region.
Date Issued
1993
PURL
http://purl.flvc.org/fcla/dt/14912
Subject Headings
Metallocenes, Organometallic polymers, Infrared spectroscopy, Azo compounds
Format
Document (PDF)
Synthesis and characterization of tin-containing polymers derived from amino acids
Title
Synthesis and characterization of tin-containing polymers derived from amino acids.
Creator
Li, Fengmai, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Tin-containing polymers were synthesized by reaction of amino acids (4-aminobenzoic acid, ampicillin, glycylglycine and glycyl-D-phenylalanine) with organotin dichloride via the interfacial condensation technique. The products were characterized using Fourier Transform Infrared spectrometry, Ultraviolet spectrometry, light scattering photometry and mass spectral analysis. The biological activities of the products were tested against selected microorganisms and human cells.
Date Issued
1998
PURL
http://purl.flvc.org/fcla/dt/15611
Subject Headings
Organometallic polymers, Organotin compounds
Format
Document (PDF)
Synthesis and structural characterization of intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease
Title
Synthesis and structural characterization of intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease.
Creator
Chamely-Wiik, Donna M., Florida Atlantic University, Haky, Jerome E., Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
We have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that...
Show moreWe have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that had a unique set of characteristics. Upon reduction of the N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-benzyloxyphenyl)-L-alanine benzylester, which contained a ketone moiety, to produce the secondary alcohol, we discovered that the materials that were formed included a pair of diastereomers of the secondary alcohol, each diastereomer also exhibiting two individually stable conformational isomers. We believe that the conformational isomers were generated by rotation of the C-N bond of the BOC carbamate, and were so stable that they could be separated by HPLC and NMR techniques. Energy optimization studies and molecular modeling techniques were performed using HyperChem, and rotational barrier energy values were calculated for the different conformational isomers for each of the diastereomers. HPLC and NMR techniques were also used to obtain information about these materials. Using the calculated data from these studies, and analyzing the HPLC chromatograms and NMR spectra we were able to fully determine the assignments for the diastereomers and the individual conformational isomers. We discovered that the SS form was synthesized preferentially over the SR form and that in both cases the E conformation was energetically more stable than the Z form. Octanol/water partition coefficient values (Log P0ct) were also determined and compared to L-dopa and dopamine. We concluded that the values for the dimeric compound that we synthesized and many of its potential products of degradation were significantly higher than that for both L-dopa and dopamine. This may be an indication that this material has a higher degree of lipophilicity than L-dopa itself, having more potential to cross the blood brain barrier. We believe that these intermediate materials serve as good indication of how a polyphosphonate ester containing L-dopa would compare as a potential drug for Parkinson's disease.
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Date Issued
2004
PURL
http://purl.flvc.org/fcla/dt/12108
Subject Headings
Parkinson's disease--Treatment, Antiparkinsonian agents, Dopa, Organophosphorus compounds--Synthesis, Chemistry, Analytic
Format
Document (PDF)
synthesis of a new polymeric ligand poly[5-(1,3-bis-(2'-pyridylimino)isoindolyloxy)ethylene] (PBPIIIOE)
Title
The synthesis of a new polymeric ligand poly[5-(1,3-bis-(2'-pyridylimino)isoindolyloxy)ethylene] (PBPIIIOE).
Creator
Jiang, Yi, Florida Atlantic University, Carraher, Charles E., Baird, Donald M., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
A new polymeric ligand, poly[5-(1,3-bis-(2'-pyridylimino) isoindolyloxy)ethylene], was synthesized. At same time, 1,3-bis-(2 '-pyridylimino)-5-hexadecanyloxyisoindoline was also synthesized. These two products were characterized with fourier transform infrared spectrometry, ultraviolet spectrometry, mass spectral analysis and elemental analysis. Their complexes of Cu+2 were prepared.
Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/12663
Subject Headings
Ligands, Organometallic polymers
Format
Document (PDF)