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Title: Hapaioside: a 19-norpregnane glycoside from the sponge Cribrochalina olemda.
Creator: Yeung, Bryan K. S., Hamann, Mark T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3331882
Subject Headings: Sponges, Glycosides, Pregnane, Saponins
Format: Document (PDF)

Title: Strategies for flow cytometric analysis of marine microalgae and sponge cells.
Creator: Yentsch, C. M., Pomponi, Shirley A.
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3353886
Subject Headings: Microalgae, Sponges, Cytometric cellular analysis
Format: Document (PDF)

Title: A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Creator: Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
Date Issued: 2003
PURL: http://purl.flvc.org/FCLA/DT/3351980
Subject Headings: Sponges, Sesterterpenes, Marine natural products
Format: Document (PDF)

Title: A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer.
Creator: Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Chen, Guodong, Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Chu, Min
Date Issued: 2003
PURL: http://purl.flvc.org/fau/fd/FA00007361
Subject Headings: Sponges, Alkaloids, Guanidines, Antibacterial agents, Molecular structure
Format: Document (PDF)

Title: A New Sterol Sulfate, Sch 572423, from a Marine Sponge, Topsentia sp.
Creator: Yang, Shu-Wei, Buevich, Alexei, Chan, Tze-Ming, Smith, Michelle, Lachowicz, Jean, Pomponi, Shirley A., Wright, Amy E., Mierzwa, Ronald, Patel, Mahesh, Gullo, Vincent, Chu, Min
Date Issued: 2003
PURL: http://purl.flvc.org/FCLA/DT/2827816
Subject Headings: Water quality bioassay, Water --Pollution --Toxicology, Sponges, Marine ecosystem management, Filters and filtration
Format: Document (PDF)

Title: Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator: Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued: 2007
PURL: http://purl.flvc.org/FCLA/DT/3333011
Subject Headings: Sponges, Macrolides, Marine natural products
Format: Document (PDF)

Title: (+)-Curcuphenol and (+)-Curcudiol, sesquiterpene phenols from shallow and deep water collections of the marine sponge Didiscus Flavus.
Creator: Wright, Amy E., Pomponi, Shirley A., McConnell, O. J., Kohmoto, S., McCarthy, Peter J.
Date Issued: 1987
PURL: http://purl.flvc.org/FCLA/DT/3332940
Subject Headings: Sponges, Sesquiterpenes, Antifungal agents, Marine metabolites
Format: Document (PDF)

Title: 3-amino-1-(2-aminoimidazolyl)-prop-i-ene from the marine sponges Teichaxinella morchella and Ptilocaulis walpersi.
Creator: Wright, Amy E., Chiles, S. A., Cross, S. S.
Date Issued: 1991
PURL: http://purl.flvc.org/FCLA/DT/3332990
Subject Headings: Sponges, Marine metabolites, Pyrroles
Format: Document (PDF)

Title: Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
Creator: Wright, Amy E., Chen, Ying, Winder, Priscilla L., Pitts, Tara P., Pomponi, Shirley A., Longley, Ross E.
Date Issued: 2004
PURL: http://purl.flvc.org/FCLA/DT/3164109
Subject Headings: Macrolide antibiotics, Natural products, Mass spectrometry, Sponges, Stereochemistry
Format: Document (PDF)

Title: A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites.
Creator: Wright, Amy E., Pomponi, Shirley A., Cross, S. S., McCarthy, Peter J.
Date Issued: 1992
PURL: http://purl.flvc.org/FCLA/DT/3333002
Subject Headings: Sponges, Indole alkaloids, Marine natural products
Format: Document (PDF)

Title: An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani.
Creator: Wright, Amy E., Rueth, S. A., Cross, S. S.
Date Issued: 1991
PURL: http://purl.flvc.org/FCLA/DT/3332987
Subject Headings: Sponges, Sesquiterpenes, Marine natural products, Spectroscopy
Format: Document (PDF)

Title: The Lithistida: important sources of compounds useful in biomedical research.
Creator: Wright, Amy E.
Date Issued: 2010
PURL: http://purl.flvc.org/FCLA/DT/3331940
Subject Headings: Sponges, Biomedical research, Marine natural products, Bioactive compounds
Format: Document (PDF)

Title: Sulfircin: a new sesterterpene sulfate from a deep-water sponge of the genus Ircinia.
Creator: Wright, Amy E., McCarthy, Peter J., Schulte, G. K.
Date Issued: 1989
PURL: http://purl.flvc.org/FCLA/DT/3332962
Subject Headings: Sponges, Sulfates, Sesterterpenes, Antifungal agents, Marine natural products
Format: Document (PDF)

Title: Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura.
Creator: Wright, Amy E., McConnell, O. J., Kohmoto, S., Lui, M. S., Thompson, W., Snader, K. M.
Date Issued: 1987
PURL: http://purl.flvc.org/FCLA/DT/3353798
Subject Headings: Cytotoxin, Sponges, Marine natural products, Polyacetylenes
Format: Document (PDF)

Title: Therapeutic potential, mechanism of action, and ecology of novel marine natural products.
Creator: Winder, Priscilla L., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: The projects described in this dissertation are focused on compounds derived from the marine environment. Chapter 1 gives an introduction to the study of marine natural products to treat human ailments and a thorough review on compounds from lithistid sponges that have been isolated or synthesized since 2000. Chapter 2 describes the isolation and structure elucidation of two sesquiterpene substituted benzoquinone derivatives, petrosiquinones A and B, from a deep-water marine sponge from the...
Show moreThe projects described in this dissertation are focused on compounds derived from the marine environment. Chapter 1 gives an introduction to the study of marine natural products to treat human ailments and a thorough review on compounds from lithistid sponges that have been isolated or synthesized since 2000. Chapter 2 describes the isolation and structure elucidation of two sesquiterpene substituted benzoquinone derivatives, petrosiquinones A and B, from a deep-water marine sponge from the Family Petrosiidae. Although initially purified following activity in a (Sb(B-catenin/Tcf4 assay they were later followed using tumor cell line cytotoxicity assays. Petrosiquinone A was the more active of the two compounds with moderate cytotoxicity in the DLD-1, PANC-1, and AsPC-1 cell lines. In Chapter 3, the isolation and structure elucidation of two new marine-derived macrolides, madeirolide A and B, isolated from a deep-water lithistid sponge of the genus Leiodermatium is described., They were isolated using numerous chromatographic techniques and the structures were elucidated on the basis of 1D and 2D NMR spectra coupled with high resolution-mass spectrometry (HR-MS) data. Madeirolide A and B inhibited the growth of the fungal pathogen Candida albicans with minimum inhibitory concentrations (MIC) of 12.5 and 25 (So(Bg/mL, respectively, but were not cytotoxic in tumor cell assays under the conditions tested. Chapter 4 describes work performed to determine the molecular target of lasonolide A using affinity chromatography. The target of lasonolide A is of interest since lasonolide A is known to kill cancer cells in vitro through a unique mechanism., This chapter highlights the research performed to create an affinity matrix with immobilized lasonolide. A target has not been confirmed but there are a number of interesting hits that are being pursued. In Chapter 5, a liquid chromatography-mass spectrometry (LC-MS) screening method was established in order to rapidly identify the metabolites from numerous collections of Lyngbya spp. obtained from Broward and Lee County, Florida sites that may help marine ecologists assess the effects of Lyngbya spp. blooms on the environment. A link between the metabolites produced and nutrients from both the algal tissue and water column was also explored.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/369392
Subject Headings: Natural products, Therapeutic use, Sponges, Ecology, Marine resources, Research, Marine biotechnology
Format: Document (PDF)

Title: Characterization, biosynthetic studies and subcellular localization of sterols from the marine sponge Teichaxinella morchella.
Creator: Williams, Amanda Joy, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: A-nor sterols have been isolated and characterized from the marine sponge Teichaxinella morchella using High Performance Liquid Chromatography, Nuclear Magnetic Resonance, and Mass Spectrometry. A cell free extract of T. morchella was used to determine the biosynthetic origin of the sterols. Incubation experiments with radiolabled Farnesyl Pyrophosphate and cholesterol showed that the sterols are coming from a dietary source. Subcellular localization studies showed that the sterols are part...
Show moreA-nor sterols have been isolated and characterized from the marine sponge Teichaxinella morchella using High Performance Liquid Chromatography, Nuclear Magnetic Resonance, and Mass Spectrometry. A cell free extract of T. morchella was used to determine the biosynthetic origin of the sterols. Incubation experiments with radiolabled Farnesyl Pyrophosphate and cholesterol showed that the sterols are coming from a dietary source. Subcellular localization studies showed that the sterols are part of the cell membrane.
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Date Issued: 2001
PURL: http://purl.flvc.org/fcla/dt/12865
Subject Headings: Sponges, Sterols
Format: Document (PDF)

Title: A new deep sea coralline sponge from Turks and Caicos Islands: Willardi caicosensis gen. et sp. nov.(Demospongiae: Hadromerida).
Creator: Willenz, P., Pomponi, Shirley A.
Date Issued: 1996
PURL: http://purl.flvc.org/fau/fd/FA00007343
Subject Headings: Turks and Caicos Islands, Atlantic Ocean, Sponges, Demospongiae, Coralline, Species, Genus
Format: Document (PDF)

Title: EVALUATION OF 3-D CULTURE METHODS FOR MARINE SPONGES.
Creator: Urban-Gedamke, Elizabeth, Pomponi, Shirley A., Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
Abstract/Description: Marine sponges are economically and environmentally valuable, but restoration, commercial, and biomedical demands exceed what wild populations and aquaculture can provide. In vitro culture of sponge cells is a promising alternative, but has remained elusive until recent breakthroughs involving improved nutrient medium M1 in two-dimensional culture. The advantages of three-dimensional over two-dimensional cell culture have been increasingly recognized. Here we report the successful 21-day...
Show moreMarine sponges are economically and environmentally valuable, but restoration, commercial, and biomedical demands exceed what wild populations and aquaculture can provide. In vitro culture of sponge cells is a promising alternative, but has remained elusive until recent breakthroughs involving improved nutrient medium M1 in two-dimensional culture. The advantages of three-dimensional over two-dimensional cell culture have been increasingly recognized. Here we report the successful 21-day culture of cells from the marine sponge Geodia neptuni using multiple three-dimensional cell culture methods: FibraCel© disks, thin hydrogel layers, gel micro droplets, and spheroid cell culture. These methods performed comparably to two-dimensional control cultures, and each method offers advantages for restoration or in vitro applications using sponge cells. Further optimization of these methods may lead to the ability to culture fully functioning sponges from dissociated, cryopreserved cells, which will reduce the need for wild harvest of sponge tissues for commercial, restoration, and biomedical purposes.
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Date Issued: 2021
PURL: http://purl.flvc.org/fau/fd/FA00013726
Subject Headings: Sponges, Cell Culture--methods
Format: Document (PDF)

Title: Isobatzellines A, B, C, and D. Cytotoxic and antifungal pyrroloquinoline alkaloids from the marine sponge Batzella sp.
Creator: Sun, H. H., Sakemi, S., Burres, N. S., McCarthy, Peter J.
Date Issued: 1990
PURL: http://purl.flvc.org/FCLA/DT/3332970
Subject Headings: Sponges, Alkaloids, Pyrroles, Quinolines, Poecilosclerida
Format: Document (PDF)

Title: A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
Creator: Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
Date Issued: 1991
PURL: http://purl.flvc.org/FCLA/DT/3332982
Subject Headings: Sponges, Indoles, Marine natural products
Format: Document (PDF)

HBOI Faculty Contributions (123)	+ -
FAU Theses and Dissertations (9)	+ -
FAU Graduate Student Research (1)	+ -
HBOI Technical Reports (1)	+ -

Marine natural products (30)	+ -
Marine metabolites (15)	+ -
Alkaloids (14)	+ -
Bioactive compounds (11)	+ -
Demospongiae (11)	+ -

Antineoplastic agents (10)	+ -
Porifera (10)	+ -
Chemical structure (8)	+ -
Cytotoxin (8)	+ -
Macrolides (7)	+ -
Cytotoxins (5)	+ -
Natural products (5)	+ -
Sesquiterpenes (5)	+ -
Antifungal agents (4)	+ -
Cell culture (4)	+ -
Ecology (4)	+ -
Marine pharmacology (4)	+ -
Polyketides (4)	+ -
Stereochemistry (4)	+ -
Sterols (4)	+ -
Symbiosis (4)	+ -
Acridines (3)	+ -
Algae (3)	+ -
Antiviral agents (3)	+ -
Immunosuppressive agents (3)	+ -
Indole Alkaloids (3)	+ -
Lactones (3)	+ -
Microbial ecology (3)	+ -
Nuclear magnetic resonance spectroscopy (3)	+ -

article (123)	+ -
Electronic Thesis or Dissertation (9)	+ -
abstract (1)	+ -
technical report (1)	+ -

Harbor Branch Oceanographic Institute (51)	+ -
Pomponi, Shirley A. (48)	+ -
Wright, Amy E. (35)	+ -
McCarthy, Peter J. (24)	+ -
Gunasekera, Sarath P. (21)	+ -

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