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MULTIPHYSICS SIMULATION OF DIELECTROPHORESIS ENRICHMENT FOR DETECTION OF LOW PARASITEMIA PLASMODIUM FALCIPARUM IN HUMAN BLOOD
| Title: | MULTIPHYSICS SIMULATION OF DIELECTROPHORESIS ENRICHMENT FOR DETECTION OF LOW PARASITEMIA PLASMODIUM FALCIPARUM IN HUMAN BLOOD. |
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| Name(s): |
Oladokun, Oladiran , author Du, E. , Thesis advisor Florida Atlantic University, Degree grantor Department of Ocean and Mechanical Engineering College of Engineering and Computer Science |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2024 | |
| Date Issued: | 2024 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 117 p. | |
| Language(s): | English | |
| Abstract/Description: | Malaria is an ancient lethargic disease that remains a global burden. It has been difficult to end the scourge of P. falciparum malaria because of the parasites’ drug resistance so early diagnosis of malaria is crucial. Microscopy remains the gold standard but has limited reliability in detecting malaria parasites. This study proffered a method towards detection of low parasitemia P. falciparum infected RBCs (Pf-RBCs) based on dielectrophoresis (DEP). A microfluidic device was designed for label-free cell sorting of Pf-RBCs from other whole blood in a continuous manner, based on the intrinsic electrical signatures of the cells. The design was validated by a finite element simulation using COMSOL Multiphysics. Simulations show the feasibility of the separation in a 9-mm long microfluidic channel under laminar flow conditions, using a low voltage supply of +/-10 V at 50 kHz. | |
| Identifier: | FA00014415 (IID) | |
| Degree granted: | Thesis (MS)--Florida Atlantic University, 2024. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Plasmodium falciparum Microfluidic devices Dielectrophoresis Biomedical engineering Point-of-care testing |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00014415 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
