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Isolation and characterization of novel conopeptides from Conus nux

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Date Issued:
2002
Summary:
Cone snails are marine gastropods belonging to the genus Conus that inhabit in tropical habitats throughout the world. They are predators that paralyze their prey by injection of venom, containing a complex mixture of conopeptides. The venom of cone snails has been found to be a valuable source of specific drugs for disorders ranging from stroke to chronic pain. For this work, the venom of Conus nux, a Panamic cone snail species, was extracted and analyzed. Components of the venom were isolated using Size Exclusion Chromatography (SEC) and Reversed Phase High Performance Liquid Chromatography techniques. A novel conopeptide sequence, determined by Edman Degradation is reported. The arrangement of the cysteines residues within this sequence suggest that it member of the M-superfamily of conotoxins.
Title: Isolation and characterization of novel conopeptides from Conus nux.
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Name(s): Ramlakhan, Rani Elizabeth.
Florida Atlantic University, Degree grantor
Mari, Frank, Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2002
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 82 p.
Language(s): English
Summary: Cone snails are marine gastropods belonging to the genus Conus that inhabit in tropical habitats throughout the world. They are predators that paralyze their prey by injection of venom, containing a complex mixture of conopeptides. The venom of cone snails has been found to be a valuable source of specific drugs for disorders ranging from stroke to chronic pain. For this work, the venom of Conus nux, a Panamic cone snail species, was extracted and analyzed. Components of the venom were isolated using Size Exclusion Chromatography (SEC) and Reversed Phase High Performance Liquid Chromatography techniques. A novel conopeptide sequence, determined by Edman Degradation is reported. The arrangement of the cysteines residues within this sequence suggest that it member of the M-superfamily of conotoxins.
Identifier: 9780493913117 (isbn), 12951 (digitool), FADT12951 (IID), fau:9821 (fedora)
Note(s): Thesis (M.S.)--Florida Atlantic University, 2002.
Charles E. Schmidt College of Science
Subject(s): Conus
Gastropoda--Venom
Venom
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/12951
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.