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DEVELOPMENT OF A HIFI-Α LENS SPECIFIC KNOCKOUT MOUSE AS A MODEL FOR HYPOXIA DRIVEN LENS DIFFERENTIATION
| Title: | DEVELOPMENT OF A HIFI-Α LENS SPECIFIC KNOCKOUT MOUSE AS A MODEL FOR HYPOXIA DRIVEN LENS DIFFERENTIATION. |
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| Name(s): |
Adele, Adedamola , author Kantorow, Marc , Thesis advisor Florida Atlantic University, Degree grantor Department of Biomedical Science Charles E. Schmidt College of Medicine |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2023 | |
| Date Issued: | 2023 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 31 p. | |
| Language(s): | English | |
| Abstract/Description: | During eye lens development the lens receives oxygen from a network of capillaries that comprise of the tunica vasculosa lentis and the anterior pupillary membrane. In development there is regression of this capillaries with the vitreous and aqueous humor, which is the lens only source of oxygen, leaving the lens in low oxygen state. The lens contains a decreasing oxygen gradient from the surface to the core that parallels the differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 alpha (HIF1a), in the regulation of genes required for lens fiber cell differentiation, structure, and transparency. Previous studies by our lab discovered the HIF1a-dependent gene expression patterns of lens genes by utilizing a Multiomics approach that integrated analysis from CUT&RUN, RNA-seq, and ATACseq. Additionally, our lab also established a hypoxia and HIF1a-dependent mechanism for the non-nuclear organelle degradation process required to form mature transparent fiber cells. | |
| Identifier: | FA00014167 (IID) | |
| Degree granted: | Thesis (MS)--Florida Atlantic University, 2023. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Cell differentiation Lens, Crystalline Eye lens |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00014167 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
