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Radiation Induced Injury of Hepatocellular Carcinoma, IMRT vs SBRT
| Title: | Radiation Induced Injury of Hepatocellular Carcinoma, IMRT vs SBRT. |
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| Name(s): |
Feghhi, Touhid , author Pella, Silvia , Thesis advisor Florida Atlantic University, Degree grantor Department of Physics Charles E. Schmidt College of Science |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2022 | |
| Date Issued: | 2022 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 71 p. | |
| Language(s): | English | |
| Abstract/Description: | Hepatocellular carcinoma is currently one of the most fatal cancers in the world. The routine treatment for this type of cancer consists of surgery, chemotherapy, and finally radiation therapy. Recent advancements in technology have enabled us to deliver highly conformed dose to planning target volume. Two of these methods are Intensity modulated Radiation Therapy (IMRT) and Stereotactic Body Radiation Therapy (SBRT). The difference between these two methods is that in the SBRT high radiation dose per fraction is delivered, but smaller number of fractions which renders better tumor control probability. However, better tumor control comes at the price of complications and radiation induced liver damage. In this work, we compare the outcome of radiation with regards to the probability of radiation damage to the liver after IMRT and SBRT. For this purpose, we analyzed 10 anonymized patients’ data with liver cancer, and we made two similar treatment plans for them. The difference in two plans is dose per fraction and total dose. After optimizing the treatments and calculating the dose volume histogram, we found the effective volume of the liver being irradiated. Finally, this effective volume and the corresponding dose were used to show that SBRT has the advantage of better tumor control probability at the cost of higher probability of complications. | |
| Identifier: | FA00014070 (IID) | |
| Degree granted: | Thesis (PSM)--Florida Atlantic University, 2021. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Carcinoma, Hepatocellular Radiotherapy--Adverse effects Radiotherapy, Intensity-Modulated Stereotactic Body Radiation Therapy |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00014070 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
