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Ion homeostasis and energy loss in the anoxic frog brain (Rana pipiens)

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Date Issued:
2000
Summary:
This study investigated the homeostasis of extracellular potassium ion concentration ([K+]e) and correlated energy levels in the anoxic frog brain (Rana pipiens). The results showed K+ ion homeostasis was maintained for 3hrs in anoxia. It confirmed a constant decline in brain ATP in anoxia. It was concluded that ion homeostasis in the frog does not rely on the maintenance of normoxic levels of ATP. When Na+/K+ATPase was inhibited, it was found that initial K+ efflux was decreased in the anoxic frog. This could be due to decreased ion permeability in anoxia, an adaptive strategy seen in other anoxic tolerant organisms. However, the study showed once a threshold [K+]e was reached, the final K + efflux pattern was unchanged. This [K+]e appears to represent a membrane potential threshold. Critical energy levels were determined representing the energy minimum to maintain ion homeostasis in the anoxic frog brain.
Title: Ion homeostasis and energy loss in the anoxic frog brain (Rana pipiens).
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Name(s): Knickerbocker, Debra L.
Florida Atlantic University, Degree grantor
Lutz, Peter L., Thesis advisor
Charles E. Schmidt College of Science
Department of Biological Sciences
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2000
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, FL
Physical Form: application/pdf
Extent: 49 p.
Language(s): English
Summary: This study investigated the homeostasis of extracellular potassium ion concentration ([K+]e) and correlated energy levels in the anoxic frog brain (Rana pipiens). The results showed K+ ion homeostasis was maintained for 3hrs in anoxia. It confirmed a constant decline in brain ATP in anoxia. It was concluded that ion homeostasis in the frog does not rely on the maintenance of normoxic levels of ATP. When Na+/K+ATPase was inhibited, it was found that initial K+ efflux was decreased in the anoxic frog. This could be due to decreased ion permeability in anoxia, an adaptive strategy seen in other anoxic tolerant organisms. However, the study showed once a threshold [K+]e was reached, the final K + efflux pattern was unchanged. This [K+]e appears to represent a membrane potential threshold. Critical energy levels were determined representing the energy minimum to maintain ion homeostasis in the anoxic frog brain.
Identifier: 9780599955356 (isbn), 12717 (digitool), FADT12717 (IID), fau:9598 (fedora)
Degree granted: Thesis (M.S.)--Florida Atlantic University, 2000.
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Charles E. Schmidt College of Science
Subject(s): Northern leopard frog
Cerebral anoxia
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/12717
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.