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Maternal neuroendocrine function and fetal development
| Title: | Maternal neuroendocrine function and fetal development. |
 181 views 106 downloads |
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| Name(s): |
Diego, Miguel Angel Florida Atlantic University, Degree Grantor Jones, Nancy Aaron, Thesis Advisor |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 2004 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 103 p. | |
| Language(s): | English | |
| Summary: | Maternal neuroendocrine function during pregnancy has been related to a number of pregnancy outcomes including less optimal fetal growth patterns. Animal models have consistently demonstrated that glucocorticoid infusions to the mother result in fetal growth restriction and norepinephrine infusions in reduced blood flow to the fetus. Similarly, human studies reveal that elevated maternal HPA axis and adrenal function (associated with stress anxiety and depression) during pregnancy is related to prematurity and low birthweight. The present study examined the relationship between maternal cortisol and norepinephrine and fetal growth measures during mid-gestation. Correlation analyses revealed that both maternal psychological (daily hassles, depression and anxiety) and biochemical (cortisol and norepinephrine) variables were negatively related to fetal growth measures. Hierarchical multiple regression analyses further revealed that maternal cortisol was the best single maternal predictor of fetal growth accounting for a significant portion of the variance even after controlling for gestational age and fetal gender. Results from the structural equation model indicate that the effects of maternal psychological distress on fetal growth are mediated by maternal cortisol. Potential mechanisms of action are discussed. | |
| Identifier: | 9780496868803 (isbn), 12100 (digitool), FADT12100 (IID), fau:9010 (fedora) | |
| Note(s): | Thesis (Ph.D.)--Florida Atlantic University, 2004. | |
| Subject(s): |
Neuroendocrinology Pregnancy Fetus--Growth Maternal-fetal exchange Developmental psychobiology Comparative neurobiology |
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| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/12100 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
