You are here

Compositions and Methods for Treating Neural Anoxia and Spreading Depression, 2011

Download pdf | Full Screen View

Date Issued:
2011
Abstract/Description:
Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines.
Title: Compositions and Methods for Treating Neural Anoxia and Spreading Depression, 2011.
14 views
4 downloads
Name(s): Dawson-Scully, Ken, author
Robertson, R. Meldrum
Florida Atlantic University
Armstrong, Gary A.B.
Type of Resource: text
Genre: Patent
Date Created: 2011
Date Issued: 2011
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, FL
Physical Form: application/pdf
Extent: 29 p.
Language(s): English
Abstract/Description: Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines.
Identifier: FAUIR000256 (IID)
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FAUIR000256
Use and Reproduction: All rights reserved by the source institution
Host Institution: FAU