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Compositions and Methods for Treating Neural Anoxia and Spreading Depression, 2009
| Title: | Compositions and Methods for Treating Neural Anoxia and Spreading Depression, 2009. |
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| Name(s): |
Dawson-Scully, Ken, author Robertson, R. Meldrum Florida Atlantic University Armstrong, Gary A.B. |
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| Type of Resource: | text | |
| Genre: | Patent | |
| Date Created: | 2009 | |
| Date Issued: | 2009 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, FL | |
| Physical Form: | application/pdf | |
| Extent: | 30 p. | |
| Language(s): | English | |
| Abstract/Description: | Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines. | |
| Identifier: | FAUIR000255 (IID) | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FAUIR000255 | |
| Use and Reproduction: | All rights reserved by the source institution | |
| Host Institution: | FAU |
