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Chemistry and biology of the discodermolides, potent mitotic spindle poisons
| Title: | Chemistry and biology of the discodermolides, potent mitotic spindle poisons. |
 123 views 19 downloads |
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| Name(s): |
Gunasekera, Sarath P., creator Wright, Amy E., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2005 | |
| Publisher: | Taylor & Francis Group | |
| Extent: | 34 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3352941 (digitool), FADT3352941 (IID), fau:6566 (fedora), 10.1201/b11185-11 (doi) | |
| Note(s): |
(+)-Discodermolide (1) is a highly functionalized, marine sponge-derived polyketide 8-lactone presumably formed by a combination of propionate and acetate units. 1 was first isolated and characterized by Gunasekera et al. [ at the Harbor Branch Oceanographic Institution (HBOI) from the marine sponge Discodermia dissoluta Crude extracts of the sponge showed strong potency against the murine P388 lymphocytic leukemia cell line, and bioassay-guided fractionation using this assay resulted in the purification of 1. This is an electronic published version of an article which may be cited as: Gunasekera, S. P., & Wright, A. E. (2005). Chemistry and biology of the discodermolides, potent mitotic spindle poisons. In G. M. Cragg, D. G. I. Kingston, & D. J. Newman (eds.), Anticancer Agents from Natural Products. (pp. 171-189). Boca Raton, FL: Taylor & Francis. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1603. |
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| Subject(s): |
Polyketides Sponges Immunosuppressive agents Antimitotic agents Chemistry Biology |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3352941 | |
| Links: | https://doi.org/10.1201/b11185-11 | |
| Restrictions on Access: | ©2005 Taylor & Francis Group | |
| Host Institution: | FAU |
