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Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae

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Date Issued:
2007
Title: Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
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Name(s): Wright, Amy E., creator
Botelho, J. C., creator
Guzman, Esther A., creator
Harmody, Dedra K., creator
Linley, P. A., creator
McCarthy, Peter J., creator
Pitts, Tara P., creator
Pomponi, Shirley A., creator
Reed, John K., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2007
Publisher: The American Chemical Society and American Society of Pharmacognosy
Extent: 6 p.
Physical Description: pdf
Language(s): English
Identifier: 3333011 (digitool), FADT3333011 (IID), fau:6208 (fedora), 10.1021/np060597h (doi)
Note(s): A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 µg/mL.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np060597h. This article may be cited as: Wright, A. E., Botelho, J. C., Guzmán, E., Harmody, D., Linley, P., McCarthy, P. J., Pitts, T. P., Pomponi, S. A., & Reed, J. K. (2007). Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae. Journal of Natural Products, 70(3), 412-416. doi:10.1021/np060597h
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1649.
Subject(s): Sponges
Macrolides
Marine natural products
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3333011
Links: http://dx.doi.org/10.1021/np060597h
Restrictions on Access: ©2007 The American Chemical Society and American Society of Pharmacognosy
Host Institution: FAU