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Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp.

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Date Issued:
1992
Title: Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp.
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Name(s): Gulavita, N. K., creator
Gunasekera, Sarath P., creator
Pomponi, Shirley A., creator
Robinson, E. V., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1992
Publisher: American Chemical Society
Extent: 7 p.
Physical Description: pdf
Language(s): English
Identifier: 3332992 (digitool), FADT3332992 (IID), fau:6198 (fedora), 10.1021/jo00032a031 (doi)
Note(s): A depsipeptide, polydiscamide A (1)) com& of 13 amino acids including a novel amino acid 3-methylisoleucine, was isolated from a Caribbean sponge, Discodermia sp. Its structure was elucidated by means of spectroscopic, chemical degradation, and derivatization techniques. Polydiscamide A inhibits the in vitro proliferation of the cultured human lung cancer A549 cell line.
This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00032a031. This article may be cited as: Gulavita, N. K., Gunasekera, S. P., Pomponi, S. A., & Robinson, E. V. (1992). Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp. The Journal of Organic Chemistry, 57(6), 1767-1772. doi:10.1021/jo00032a031
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #880.
Subject(s): Sponges
Depsipeptides
Peptides, Cyclic
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3332992
Links: http://dx.doi.org/10.1021/jo00032a031
Restrictions on Access: ©1992 American Chemical Society
Host Institution: FAU