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Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta
| Title: | Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta. |
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| Name(s): |
Gunasekera, Sarath P., creator Gunasekera, M., creator McCarthy, Peter J., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1991 | |
| Publisher: | American Chemical Society | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3332985 (digitool), FADT3332985 (IID), fau:6195 (fedora), 10.1021/jo00016a006 (doi) | |
| Note(s): |
The genus Discodermia has been previously recognized as a source of several biological agents, calyculins A-D1 and discodermins A-D.2 In our search for biologically active substances from marine organisms, an extract from the marine sponge D. dissoluta was discovered to inhibit in vitro proliferation of P388 murine leukemia cells, to inhibit growth of Candida albicans,3 and to be active in the two-way mixed lymphocyte culture assay.4 We recently described the novel polyhydroxylated lactone discodermolide as the metabolite responsible for the immunosuppressive activity of the crude extract.5 We now report the isolation and the structure determination of the cytotoxic and antifungal active compound as discodermide (I). This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00016a006. This article may be cited as: Gunasekera, S. P., Gunasekera, M., & McCarthy, P. (1991). Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta. The Journal of Organic Chemistry, 56(16), 4830-4833. doi:10.1021/jo00016a006 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #841. |
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| Subject(s): |
Sponges Lactams, Macrocyclic Marine natural products |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3332985 | |
| Links: | http://dx.doi.org/10.1021/jo00016a006 | |
| Restrictions on Access: | ©1991 American Chemical Society | |
| Host Institution: | FAU |
