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Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
| Title: | Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. |
 151 views 41 downloads |
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| Name(s): |
Gunasekera, Sarath P., creator Gunasekera, M., creator Longley, Ross E., creator Schulte, G. K., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1990 | |
| Publisher: | American Chemical Society | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3332972 (digitool), FADT3332972 (IID), fau:6188 (fedora), 10.1021/jo00303a029 (doi) | |
| Note(s): |
A new polyhydroxylated lactone, discodermolide (l), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy, and verified by X-ray crystallographic analysis. The carbon skeleton displayed by discodermolide is new; discodermolide is immunosuppressive and cytotoxic. This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00303a029. This article may be cited as: Gunasekera, S. P., Gunasekera, M., Longley, R. E., & Schulte, G. K. (1990). Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. The Journal of Organic Chemistry, 55(16), 4912-4915. doi:10.1021/jo00303a029 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #767. |
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| Subject(s): |
Sponges Lactones Cytotoxin Antineoplastic agents NMR spectroscopy X-ray crystallography |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3332972 | |
| Links: | http://dx.doi.org/10.1021/jo00303a029 | |
| Restrictions on Access: | ©1990 American Chemical Society | |
| Host Institution: | FAU |
