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Synthesis of microcolin analogs using trimethylsilylated lactams
| Title: | Synthesis of microcolin analogs using trimethylsilylated lactams. |
 82 views 15 downloads |
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| Name(s): |
Mattern, R.-H., creator Gunasekera, Sarath P., creator McConnell, O. J., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1997 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331922 (digitool), FADT3331922 (IID), fau:6155 (fedora), 10.1016/S0040-4039(97)00336-5 (doi) | |
| Note(s): |
The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity. The synthesis of microcolin analogs using trimethylsilylated lactams is described. This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404039 and may be cited as: Mattern, R.-H., Gunasekera, S. P., & McConnell, O. J. (1997). Synthesis of microcolin analogs using trimethylsilylated lactams. Tetrahedron Letters, 38(13), 2197-2200. doi:10.1016/S0040-4039(97)00336-5 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1176. |
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| Subject(s): |
Oligopeptides Immunosuppressive agents Cytotoxin Lactams Peptides--Synthesis |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331922 | |
| Links: | http://dx.doi.org/10.1016/S0040-4039(97)00336-5 | |
| Restrictions on Access: | ©1997 Elsevier B.V. | |
| Host Institution: | FAU |
