You are here
Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide
| Title: | Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide. |
 97 views 45 downloads |
|---|---|---|
| Name(s): |
Zhang, L.-H., creator Longley, Ross E., creator Koehn, F. E., creator Harbor Branch Oceanographic Institute |
|
| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1997 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 13 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331918 (digitool), FADT3331918 (IID), fau:6153 (fedora), 10.1016/S0024-3205(96)00645-5 (doi) | |
| Note(s): |
The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mixed lymphocyte reaction (IC50 = 5.0 nM), anti-IgM (μ-chain specific) (IC50 = 10.0 nM), and phorbol 12-myristate 13-acetate plus ionomycin (IC50 = 5.8 nM) stimulation of murine splenocytes were all similarly suppressed by microcolin A. The inhibitory activity of microcolin A was time-dependent and reversible and was not associated with a reduction in cell viability. This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00243205 and may be cited as: Zhang, L.-H., Longley, R. E., & Koehn, F. E. (1997). Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide. Life Sciences, 60(10), 751-762. doi:10.1016/S0024-3205(96)00645-5 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1162. |
|
| Subject(s): |
Proliferation Immunosuppressive agents Blue-green algae Oligopeptides |
|
| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331918 | |
| Links: | http://dx.doi.org/10.1016/S0024-3205(96)00645-5 | |
| Restrictions on Access: | ©1997 Elsevier B.V. | |
| Host Institution: | FAU |
