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Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide

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Date Issued:
1997
Title: Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide.
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Name(s): Zhang, L.-H., creator
Longley, Ross E., creator
Koehn, F. E., creator
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1997
Publisher: Elsevier B.V.
Extent: 13 p.
Physical Description: pdf
Language(s): English
Identifier: 3331918 (digitool), FADT3331918 (IID), fau:6153 (fedora), 10.1016/S0024-3205(96)00645-5 (doi)
Note(s): The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mixed lymphocyte reaction (IC50 = 5.0 nM), anti-IgM (μ-chain specific) (IC50 = 10.0 nM), and phorbol 12-myristate 13-acetate plus ionomycin (IC50 = 5.8 nM) stimulation of murine splenocytes were all similarly suppressed by microcolin A. The inhibitory activity of microcolin A was time-dependent and reversible and was not associated with a reduction in cell viability.
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00243205 and may be cited as: Zhang, L.-H., Longley, R. E., & Koehn, F. E. (1997). Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide. Life Sciences, 60(10), 751-762. doi:10.1016/S0024-3205(96)00645-5
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1162.
Subject(s): Proliferation
Immunosuppressive agents
Blue-green algae
Oligopeptides
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3331918
Links: http://dx.doi.org/10.1016/S0024-3205(96)00645-5
Restrictions on Access: ©1997 Elsevier B.V.
Host Institution: FAU