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Synthesis of N-substituted Pyrrolin-2-ones
| Title: | Synthesis of N-substituted Pyrrolin-2-ones. |
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| Name(s): |
Mattern, R.-H., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1996 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331910 (digitool), FADT3331910 (IID), fau:6149 (fedora), 10.1016/0040-4039(95)02267-8 (doi) | |
| Note(s): |
During studies towards the synthesis of microcolin analogues, an unexpected dehydration was observed when 1-benzyloxycarbonyl-4-hydroxy-5-methylpyrrolidin-2-one was treated with di-tert-butyl dicarbonate in the presence of 4-dimethylaminopyridine. This reaction was used for the stereospecific synthesis of several N-protected pyrrolin-2-ones. The elimination of β-hydroxyl groups in 4-hydroxy-pyrrolidinones with di-tert-butyl dicarbonate is described. This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404039 and may be cited as: Mattern, R.-H. (1996). Synthesis of N-substituted Pyrrolin-2-ones. Tetrahedron Letters, 37(3), 291-294. doi:10.1016/0040-4039(95)02267-8 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1119. |
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| Subject(s): |
Stereoisomers--Synthesis Bioactive compounds--Synthesis Pyrrolidines |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331910 | |
| Links: | http://dx.doi.org/10.1016/0040-4039(95)02267-8 | |
| Restrictions on Access: | ©1996 Elsevier B.V. | |
| Host Institution: | FAU |
