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Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity
| Title: | Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity. |
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| Name(s): |
Koehn, F. E., creator Longley, Ross E., creator Sennett, Susan H., creator Reed, John K., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1994 | |
| Publisher: | American Chemical Society | |
| Extent: | 7 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331884 (digitool), FADT3331884 (IID), fau:6136 (fedora), 10.1021/jm00045a024 (doi) | |
| Note(s): |
A series of analogs of the immunosuppressive lipopeptide microcolin A has been prepared and evaluated for in vitro activity in the human and murine two-way mixed lymphocyte reaction. The compounds tested were obtained by semisynthetic modification and chemical degradation of the natural product. The relative potencies of these analogs suggest that the hydroxyproline and 5-methyl-3-pyrrolin-2-one portion of the molecule are important for immunosuppressive activity and that other structural elements may play an ancillary role. Methanolysis of microcolin A also led to a novel immunosuppressive lactone analog. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Medicinal Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm00045a024. This article may be cited as: Koehn, F. E., McConnell, O. J., Longley, R. E., Sennett, S. H., & Reed, J. K. (1994). Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity. Journal of Medicinal Chemistry, 37(19), 3181-3186. doi:10.1021/jm00045a024 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1050. |
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| Subject(s): |
Immunosuppressive agents Immunosuppressive agents--Mechanism of action Immunosuppressive agents--Testing Marine natural products |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331884 | |
| Links: | http://dx.doi.org/10.1021/jm00045a024 | |
| Restrictions on Access: | ©1994 American Chemical Society | |
| Host Institution: | FAU |
