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Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
| Title: | Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp. |
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| Name(s): |
Gulavita, N. K., creator Pomponi, Shirley A., creator Wright, Amy E., creator Yarwood, Donna, creator Sills, Matthew A., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1994 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331880 (digitool), FADT3331880 (IID), fau:6134 (fedora), 10.1016/0040-4039(94)85012-7 (doi) | |
| Note(s): |
A sponge of the genus Theonella collected off Perth, Australia, contained a cyclic octapeptide, perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM. The inhibition of binding could however, not be separated from the cytotoxic effects of perthamide B. The structure was elucidated by spectroscopic methods. A cyclic octapeptide perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM, was isolated from a Theonella sp. This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404039 and may be cited as: Gulavita, N. K., Pomponi, S. A., Wright, A. E., Yarwood, D., & Sills, M. A. (1994). Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp. Tetrahedron Letters, 35(37), 6815-6818. doi:10.1016/0040-4039(94)85012-7 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1047. |
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| Subject(s): |
Sponges Cyclic peptides Peptides--Structure Spectroscopic techniques |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331880 | |
| Links: | http://dx.doi.org/10.1016/0040-4039(94)85012-7 | |
| Restrictions on Access: | ©1994 Elsevier B.V. | |
| Host Institution: | FAU |
