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Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
| Title: | Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp. |
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| Name(s): |
Carney, J. R., creator Scheuer, P. J., creator Kelly-Borges, M., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1993 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331874 (digitool), FADT3331874 (IID), fau:6131 (fedora), 10.1016/S0040-4020(01)96256-8 (doi) | |
| Note(s): |
A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase-I, DNA, RNA, and protein synthesis. Makaluvamine G (5) was isolated from the sponge Histodermella sp. The compound shows significant in vitro cytotoxicity to several human tumor cell lines and inhibits topoisomerase-I (IC50 = 3 μM), RNA (15 μM), DNA (15 μM) and protein (21 μM) synthesis This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404020 and may be cited as: Carney, J. R., Scheuer, P. J., & Kelly-Borges, M. (1993). Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp. Tetrahedron, 49(38), 8483-8486. doi:10.1016/S0040-4020(01)96256-8 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #976. |
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| Subject(s): |
Sponges Cytotoxin Tryptamine--Derivatives--Synthesis Tyramine Antineoplastic agents |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331874 | |
| Links: | http://dx.doi.org/10.1016/S0040-4020(01)96256-8 | |
| Restrictions on Access: | ©1993 Elsevier B.V. | |
| Host Institution: | FAU |
