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Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.

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Date Issued:
1993
Title: Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
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Name(s): Carney, J. R., creator
Scheuer, P. J., creator
Kelly-Borges, M., creator
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1993
Publisher: Elsevier B.V.
Extent: 5 p.
Physical Description: pdf
Language(s): English
Identifier: 3331874 (digitool), FADT3331874 (IID), fau:6131 (fedora), 10.1016/S0040-4020(01)96256-8 (doi)
Note(s): A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase-I, DNA, RNA, and protein synthesis. Makaluvamine G (5) was isolated from the sponge Histodermella sp. The compound shows significant in vitro cytotoxicity to several human tumor cell lines and inhibits topoisomerase-I (IC50 = 3 μM), RNA (15 μM), DNA (15 μM) and protein (21 μM) synthesis
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404020 and may be cited as: Carney, J. R., Scheuer, P. J., & Kelly-Borges, M. (1993). Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp. Tetrahedron, 49(38), 8483-8486. doi:10.1016/S0040-4020(01)96256-8
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #976.
Subject(s): Sponges
Cytotoxin
Tryptamine--Derivatives--Synthesis
Tyramine
Antineoplastic agents
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3331874
Links: http://dx.doi.org/10.1016/S0040-4020(01)96256-8
Restrictions on Access: ©1993 Elsevier B.V.
Host Institution: FAU