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Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix

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Date Issued:
2009
Title: Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
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Name(s): Wright, Amy E., creator
Roth, G. P., creator
Hoffman, J. K., creator
Divlianska, D. B., creator
Pechter, D., creator
Sennett, Susan H., creator
Guzman, Esther A., creator
Linley, P. A., creator
McCarthy, Peter J., creator
Pitts, Tara P., creator
Pomponi, Shirley A., creator
Reed, John K., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2009
Publisher: American Chemical Society and American Society of Pharmacognosy
Extent: 7 p.
Physical Description: pdf
Language(s): English
Identifier: 3319109 (digitool), FADT3319109 (IID), fau:6045 (fedora), 10.1021/np900183v (doi)
Note(s): A new adenine-substituted bromotyrosine-derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix. Its structure was elucidated on the basis of spectral data and confirmed through a convergent, modular total synthetic route that is amenable toward future analogue preparation.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np900183v. This article may be cited as: Wright, A. E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, S. H., Guzman, E. A., Linley, P., McCarthy, P. J., Pitts, T. P., Pomponi, S. A., & Reed, J K. (2009). Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix. Journal of Natural Products, 72(6), 1178-1183. doi:10.1021/np900183v
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1733.
Subject(s): Sponges --Research
Marine metabolites
Marine natural products
Hexactinellida
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3319109
Links: http://dx.doi.org/10.1021/np900183v
Restrictions on Access: ©2009 American Chemical Society and American Society of Pharmacognosy
Host Institution: FAU