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Five new Discodermolide analogues from the marine sponge Discodermia species

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Date Issued:
2002
Title: Five new Discodermolide analogues from the marine sponge Discodermia species.
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Name(s): Gunasekera, Sarath P., creator
Paul, Gopal K., creator
Longley, Ross E., creator
Isbrucker, Richard A., creator
Pomponi, Shirley A., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2002
Publisher: American Chemical Society and American Society of Pharmacognosy
Physical Description: text/pdf[7p.]
Language(s): English
Identifier: 3319106 (digitool), FADT3319106 (IID), fau:6043 (fedora), 10.1021/np020219m (doi)
Note(s): Discodermolide (1) and five new discodermolide analogues trivially named 2-epi-discodermolide (2), 2-des-methyldiscodermolide (3), 5-hydroxymethyldiscodermolate (4), 19-des-aminocarbonyldiscodermolide (5), and 9(13)-cyclodiscodermolide (6) have been isolated from marine sponges belonging to the genus Discodermia collected from the Caribbean Sea. The isolation, structure elucidation, and biological activities of 2−6 are described.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np020219m. This article may be cited as: Gunasekera, S. P., Paul, G. K., Longley, R. E., Isbrucker, R. A., & Pomponi, S. A. (2002). Five new Discodermolide analogues from the marine sponge Discodermia species. Journal of Natural Products, 65(11), 1643-1648. doi:10.1021/np020219m
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1482.
Subject(s): Sponges --Research
Cytotoxin
Marine natural products
Polyketides
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3319106
Links: http://dx.doi.org/10.1021/np020219m
Restrictions on Access: ©2002 American Chemical Society and American Society of Pharmacognosy
Host Institution: FAU