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Five new Discodermolide analogues from the marine sponge Discodermia species
| Title: | Five new Discodermolide analogues from the marine sponge Discodermia species. |
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| Name(s): |
Gunasekera, Sarath P., creator Paul, Gopal K., creator Longley, Ross E., creator Isbrucker, Richard A., creator Pomponi, Shirley A., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2002 | |
| Publisher: | American Chemical Society and American Society of Pharmacognosy | |
| Physical Description: | text/pdf[7p.] | |
| Language(s): | English | |
| Identifier: | 3319106 (digitool), FADT3319106 (IID), fau:6043 (fedora), 10.1021/np020219m (doi) | |
| Note(s): |
Discodermolide (1) and five new discodermolide analogues trivially named 2-epi-discodermolide (2), 2-des-methyldiscodermolide (3), 5-hydroxymethyldiscodermolate (4), 19-des-aminocarbonyldiscodermolide (5), and 9(13)-cyclodiscodermolide (6) have been isolated from marine sponges belonging to the genus Discodermia collected from the Caribbean Sea. The isolation, structure elucidation, and biological activities of 2−6 are described. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np020219m. This article may be cited as: Gunasekera, S. P., Paul, G. K., Longley, R. E., Isbrucker, R. A., & Pomponi, S. A. (2002). Five new Discodermolide analogues from the marine sponge Discodermia species. Journal of Natural Products, 65(11), 1643-1648. doi:10.1021/np020219m Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1482. |
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| Subject(s): |
Sponges --Research Cytotoxin Marine natural products Polyketides |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3319106 | |
| Links: | http://dx.doi.org/10.1021/np020219m | |
| Restrictions on Access: | ©2002 American Chemical Society and American Society of Pharmacognosy | |
| Host Institution: | FAU |
