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Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity
| Title: | Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity. |
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| Name(s): |
Gunasekera, Sarath P., creator Longley, Ross E., creator Isbrucker, Richard A., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2001 | |
| Publisher: | American Chemical Society and American Society of Pharmacognosy | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3319101 (digitool), FADT3319101 (IID), fau:6041 (fedora), 10.1021/np000423e (doi) | |
| Note(s): |
A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured murine P-388 leukemia cells. The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np000423e. This article may be cited as: Gunasekera, S. P., Longley, R. E., & Isbrucker, R. A. (2001). Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity. Journal of Natural Products, 64(2), 171-174. doi:10.1021/np000423e Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1388. |
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| Subject(s): |
Sponges --Research Marine natural products Cytotoxin Acetylation |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3319101 | |
| Links: | http://dx.doi.org/10.1021/np000423e | |
| Restrictions on Access: | ©2001 American Chemical Society and American Society of Pharmacognosy | |
| Host Institution: | FAU |
