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Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella

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Date Issued:
1999
Title: Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
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Name(s): Gunasekera, Sarath P., creator
McCarthy, Peter J., creator
Longley, Ross E., creator
Pomponi, Shirley A., creator
Wright, Amy E., creator
Lobkovsky, E., creator
Clardy, J., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1999
Publisher: American Chemical Society and American Society of Pharmacognosy
Extent: 4 p.
Physical Description: pdf
Language(s): English
Identifier: 3319100 (digitool), FADT3319100 (IID), fau:6040 (fedora), 10.1021/np980293y (doi)
Note(s): Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np980293y. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., Longley, R. E., Pomponi, S. A., Wright, A. E., Lobkovsky, E., & Clardy, J. (1999). Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. Journal of Natural Products, 62(1), 173-175. doi:10.1021/np980293y
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1260.
Subject(s): Sponges --Research
Marine natural products
discorhabdin P
Enzyme inhibitors
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3319100
Links: http://dx.doi.org/10.1021/np980293y
Restrictions on Access: ©1999 American Chemical Society and American Society of Pharmacognosy
Host Institution: FAU