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Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels
| Title: | Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels. |
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| Name(s): |
Gunasekera, Sarath P., creator McCarthy, Peter J., creator Kelly-Borges, M., creator Lobkovsky, E., creator Clardy, J., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1996 | |
| Publisher: | American Chemical Society | |
| Extent: | 3 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3319096 (digitool), FADT3319096 (IID), fau:6038 (fedora), 10.1021/ja961961+ (doi) | |
| Note(s): |
Marine sponges continue to be a rich source of secondary metabolites with novel structures and desirable biological activity. In a continuing search for new protein phosphatase inhibitors from marine organisms, we have isolated a novel cdc25A inhibitor from the marine sponge Dysidea etheria de Laubenfels. The inhibitor, trivially named dysidiolide, is a sesterterpene γ-hydroxybutenolide, and the structure, which represents an unusual cyclization of a C25 isoprenoid, was determined by single-crystal X-ray diffraction. This document is the accepted manuscript version of a published work that appeared in final form in Journal of the American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ja961961+. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., Kelly-Borges, M., Lobkovsky, E., & Clardy, J. (1996). Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels. Journal of the American Chemical Society, 118(36), 8759-8760. doi:10.1021/ja961961+ Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1153. |
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| Subject(s): |
Sponges --Research Dysidiolide Marine metabolites Marine natural products Protein phosphatases |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3319096 | |
| Links: | http://dx.doi.org/10.1021/ja961961+ | |
| Restrictions on Access: | ©1996 American Chemical Society | |
| Host Institution: | FAU |
