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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
| Title: | Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. |
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| Name(s): |
Haar, E., creator Kowalski, R. J., creator Hamel, E., creator Lin, C. M., creator Longley, Ross E., creator Gunasekera, Sarath P., creator Rosenkranz, H. S., creator Day, B. W., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1996 | |
| Publisher: | American Chemical Society | |
| Extent: | 9 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3319092 (digitool), FADT3319092 (IID), fau:6036 (fedora), 10.1021/bi9515127 (doi) | |
| Note(s): |
Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product, was an antimitotic compound, and we confirmed this prediction. Previous work had shown an accumulation of discodermolide-treated cells in the G2/M portion of the cell cycle, and we have now found that discodermolide arrests Burkitt lymphoma cells in mitosis. This document is the accepted manuscript version of a published work that appeared in final form in Biochemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/bi9515127. This article may be cited as: Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, R. E., Gunasekera, S. P., Rosenkranz, H. S., & Day, B. W. (1996). Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 35(1), 243-250. doi:10.1021/bi9515127 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1123. |
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| Subject(s): |
Marine natural products Antimitotic agents Taxol Cytotoxin Marine toxins |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3319092 | |
| Links: | http://dx.doi.org/10.1021/bi9515127 | |
| Restrictions on Access: | ©1996 American Chemical Society | |
| Host Institution: | FAU |
