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A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi

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Date Issued:
1996
Title: A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi.
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Name(s): Gunasekera, Sarath P., creator
Kelly-Borges, M., creator
Longley, Ross E., creator
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1996
Publisher: American Chemical Society
Extent: 3 p.
Physical Description: pdf
Language(s): English
Identifier: 3319090 (digitool), FADT3319090 (IID), fau:6035 (fedora), 10.1021/np9600311 (doi)
Note(s): 24(R)-Methyl-5α-cholest-7-enyl 3β-methoxymethyl ether (1), a new sterol ether, has been isolated from a deep-water marine sponge Scleritoderma sp. cf. paccardi. Compound 1 exhibited in vitro cytotoxicity against the cultured murine P-388 tumor cell line with an IC50 of 2.3 μg/mL. The isolation and structure elucidation of 1 by NMR spectroscopy is described.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np9600311. This article may be cited as: Gunasekera, S. P., Kelly-Borges, M., & Longley, R. E. (1996). A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi. Journal of Natural Products, 59(2), 161-162. doi:10.1021/np9600311
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1117.
Subject(s): Sponges --Research
Sterols
Marine natural products
NMR spectroscopy
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3319090
Links: http://dx.doi.org/10.1021/np9600311
Restrictions on Access: ©1996 American Chemical Society
Host Institution: FAU