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New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes
| Title: | New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes. |
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| Name(s): |
Horton, P. A., creator Longley, Ross E., creator Kelly-Borges, M., creator McConnell, O. J., creator Ballas, L. M., creator Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1994 | |
| Publisher: | American Chemical Society | |
| Extent: | 9 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3319074 (digitool), FADT3319074 (IID), fau:6027 (fedora), 10.1021/np50112a006 (doi) | |
| Note(s): |
Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxyester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [S], and epiplakinic acid E methyl ester 191, were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.E-2 cell line, which correlates with signal transduction activity. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50112a006. This article may be cited as: Horton, P. A., Longley, R. E., Kelly-Borges, M., McConnell, O. J., & Ballas, L. M. (1994). New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes. Journal of Natural Products, 57(10), 1374-1381. doi:10.1021/np50112a006 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1035. |
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| Subject(s): |
Sponges --Research Marine natural products Cytotoxin |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3319074 | |
| Links: | http://dx.doi.org/10.1021/np50112a006 | |
| Restrictions on Access: | ©1994 American Chemical Society | |
| Host Institution: | FAU |
