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A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
| Title: | A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis. |
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| Name(s): |
Guzman, Esther A., creator Johnson, J. D., creator Linley, P. A., creator Wright, Amy E., creator Gunasekera, Sarath P., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2010 | |
| Publisher: | Springer Science+Business Media, LLC | |
| Extent: | 10 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3318907 (digitool), FADT3318907 (IID), fau:6008 (fedora), 10.1007/s10637-010-9422-6 (doi) | |
| Note(s): |
The effects of Manzamine A were studied in pancreatic cancer cells. Methods: AsPC-1 cells were treated for 48 h in the presence of various concentrations of Manzamine A and their phenotype, cytotoxicity, cell invasion and susceptibility to apoptosis were observed. Manzamine A decreased single cell formation, abrogated cell migration and restored the susceptibility of the cells to TRAIL-induced apoptosis in AsPC-1 cells. This manuscript is an author version with the final publication available at http://www.springerlink.com and may be cited as: Guzmán, E. A., Johnson, J. D., Linley, P. A., Gunasekera, S. E., & Wright, A. E. (2010). A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis. Investigational New Drugs, 29(5), 777-785. doi:10.1007/s10637-010-9422-6 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1807. |
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| Subject(s): |
Pancreas--Cancer Apoptosis Sponges--Research Marine natural products Drug Discovery |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3318907 | |
| Links: | http://dx.doi.org/10.1007/s10637-010-9422-6 | |
| Restrictions on Access: | ©2010 Springer Science+Business Media, LLC | |
| Host Institution: | FAU |
