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A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

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Date Issued:
2010
Title: A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
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Name(s): Guzman, Esther A., creator
Johnson, J. D., creator
Linley, P. A., creator
Wright, Amy E., creator
Gunasekera, Sarath P., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2010
Publisher: Springer Science+Business Media, LLC
Extent: 10 p.
Physical Description: pdf
Language(s): English
Identifier: 3318907 (digitool), FADT3318907 (IID), fau:6008 (fedora), 10.1007/s10637-010-9422-6 (doi)
Note(s): The effects of Manzamine A were studied in pancreatic cancer cells. Methods: AsPC-1 cells were treated for 48 h in the presence of various concentrations of Manzamine A and their phenotype, cytotoxicity, cell invasion and susceptibility to apoptosis were observed. Manzamine A decreased single cell formation, abrogated cell migration and restored the susceptibility of the cells to TRAIL-induced apoptosis in AsPC-1 cells.
This manuscript is an author version with the final publication available at http://www.springerlink.com and may be cited as: Guzmán, E. A., Johnson, J. D., Linley, P. A., Gunasekera, S. E., & Wright, A. E. (2010). A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis. Investigational New Drugs, 29(5), 777-785. doi:10.1007/s10637-010-9422-6
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1807.
Subject(s): Pancreas--Cancer
Apoptosis
Sponges--Research
Marine natural products
Drug Discovery
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3318907
Links: http://dx.doi.org/10.1007/s10637-010-9422-6
Restrictions on Access: ©2010 Springer Science+Business Media, LLC
Host Institution: FAU