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Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella
| Title: | Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella. |
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| Name(s): |
Gunasekera, Sarath P., creator McCarthy, Peter J., creator Longley, Ross E., creator Pomponi, Shirley A., creator Wright, Amy E., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1999 | |
| Publisher: | American Chemical Society | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3172682 (digitool), FADT3172682 (IID), fau:5657 (fedora), 10.1021/np990177a (doi) | |
| Note(s): |
Secobatzelline A (1), a new batzelline natural analogue, and secobatzelline B (2), a likely artifact formed during the isolation procedure, have been isolated from a deep-water marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described. This document is the accepted manuscript version of a published work that appeared in final form in Environmental Science & Technology after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np990177a. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., Longley, R. E., Pomponi, S. A., & Wright, A. E. (1999). Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella. Journal of Natural Products, 62(8), 1208–1211. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1297. |
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| Subject(s): |
Sponges --Caribbean Sea Marine natural products Toxicity testing --In vitro Phosphatases Peptidase |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3172682 | |
| Links: | http://dx.doi.org/10.1021/np990177a | |
| Restrictions on Access: | ©1999 American Chemical Society | |
| Host Institution: | FAU |
