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Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea
| Title: | Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea. |
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| Name(s): |
Reddy, N. Srinivasa, creator Reed, John K., creator Longley, Ross E., creator Wright, Amy E., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2005 | |
| Publisher: | American Chemical Society and American Society of Pharmacognosy | |
| Extent: | 4 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3164111 (digitool), FADT3164111 (IID), fau:5612 (fedora), 10.1021/np040147u (doi) | |
| Note(s): |
The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC50’s of 18.8, 2.7, and 15.6 µg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC50 of 18.7 µg/mL. This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040147u. Thisarticle may be cited as: Reddy, N. S., Reed, J. K., Longley, R. E., & Wright, A. E. (2005). TwoNew Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea. Journal of Natural Products, 68(2), 248-250. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1571. |
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| Subject(s): |
Paramuricea placomus Deep-sea ecology Cnidaria Azulene Spectrum analysis |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3164111 | |
| Links: | http://dx.doi.org/10.1021/np040147u | |
| Restrictions on Access: | ©2005 American Chemical Society and American Society of Pharmacognosy | |
| Host Institution: | FAU |
