You are here
FAU Collections » FAU Research Repository » Harbor Branch Oceanographic Institute Collection » HBOI Faculty Contributions
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
- Date Issued:
- 2004
Title: | Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp. |
![]() ![]() |
---|---|---|
Name(s): |
Wright, Amy E., creator Chen, Ying, creator Winder, Priscilla L., creator Pitts, Tara P., creator Pomponi, Shirley A., creator Longley, Ross E., creator |
|
Type of Resource: | text | |
Genre: | Article | |
Issuance: | single unit | |
Date Issued: | 2004 | |
Publisher: | American Chemical Society and American Society of Pharmacognosy | |
Extent: | 6 p. | |
Physical Description: | ||
Language(s): | English | |
Identifier: | 3164109 (digitool), FADT3164109 (IID), fau:5611 (fedora), 10.1021/np040028e (doi) | |
Note(s): |
Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50’s of 0.13, 4.5, and 0.31 µM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50’s of 0.38, 4.89, 0.57, and 15.6 µM, respectively. Compound 3 inhibits the in vitro proliferation of the NCIADR-RES cell line with an IC50 of 1.12 µM. Thisdocument is the accepted manuscript version of a published work that appeared in final formin Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040028e. Thisarticle may be cited as: Wright, A. E., Chen, Y., Winder, P. L., Pitts, T.P., Pomponi, S. A. & andLongley, R. E. (2004). Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp. Journal of Natural Products, 67(8), 1351-1355. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1555. |
|
Subject(s): |
Macrolide antibiotics Natural products Mass spectrometry Sponges Stereochemistry |
|
Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3164109 | |
Links: | http://dx.doi.org/10.1021/np040028e | |
Restrictions on Access: | ©2004 American Chemical Society and American Society of Pharmacognosy | |
Host Institution: | FAU |