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Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.

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Date Issued:
2004
Title: Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
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Name(s): Wright, Amy E., creator
Chen, Ying, creator
Winder, Priscilla L., creator
Pitts, Tara P., creator
Pomponi, Shirley A., creator
Longley, Ross E., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2004
Publisher: American Chemical Society and American Society of Pharmacognosy
Extent: 6 p.
Physical Description: pdf
Language(s): English
Identifier: 3164109 (digitool), FADT3164109 (IID), fau:5611 (fedora), 10.1021/np040028e (doi)
Note(s): Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50’s of 0.13, 4.5, and 0.31 µM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50’s of 0.38, 4.89, 0.57, and 15.6 µM, respectively. Compound 3 inhibits the in vitro proliferation of the NCIADR-RES cell line with an IC50 of 1.12 µM.
Thisdocument is the accepted manuscript version of a published work that appeared in final formin Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040028e. Thisarticle may be cited as: Wright, A. E., Chen, Y., Winder, P. L., Pitts, T.P., Pomponi, S. A. & andLongley, R. E. (2004). Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp. Journal of Natural Products, 67(8), 1351-1355.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1555.
Subject(s): Macrolide antibiotics
Natural products
Mass spectrometry
Sponges
Stereochemistry
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3164109
Links: http://dx.doi.org/10.1021/np040028e
Restrictions on Access: ©2004 American Chemical Society and American Society of Pharmacognosy
Host Institution: FAU