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Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity

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Date Issued:
2000
Title: Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity.
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Name(s): Stead, Paul, creator
Hiscox, Steve, creator
Robinson, Phil S., creator
Pike, Nicholas B., creator
Sidebottom, Philip J., creator
Roberts, Andrew D., creator
Taylor, Nicholas L., creator
Wright, Amy E., creator
Pomponi, Shirley A., creator
Langley, David, creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2000
Publisher: Elsevier Science Ltd.
Extent: 5 p.
Physical Description: pdf
Language(s): English
Identifier: 2848300 (digitool), FADT2848300 (IID), fau:5575 (fedora), 10.1016/S0960-894X(00)00063-9 (doi)
Note(s): We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro.
This is the author’s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published at http://www.elsevier.com/ and may be cited as Stead, Paul, Steve Hiscox, Phil S. Robinson, Nicholas B. Pike, Philip J. Sidebottom, Andrew D. Roberts, Nicholas L. Taylor, Amy E. Wright, Shirley A. Pomponi, David Langley (2000) Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity, Bioorganic & Medicinal Chemistry Letters 10(7):661-664 doi:10.1016/S0960-894X(00)00063-9
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1414.
Subject(s): Disaccharides --Conformations
Peptide drugs
Hepatocyte growth factor --Receptors
Sponges
Steroid harmone metabolism
Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/2848300
Links: http://dx.doi.org/10.1016/S0960-894X(00)00063-9
Restrictions on Access: ©2000 Elsevier Science Ltd.
Host Institution: FAU