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Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata
| Title: | Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata. |
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| Name(s): |
Biabani, Misbah F., creator Gunasekera, Sarath P., creator Longley, Ross E., creator Wright, Amy E., creator Pomponi, Shirley A., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2002 | |
| Publisher: | Swets & Zeitlinger | |
| Extent: | 3 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 2795916 (digitool), FADT2795916 (IID), fau:5539 (fedora), 10.1076/phbi.40.4.302.8469 (doi) | |
| Note(s): |
Tubercidin (1), a known nucleoside antibiotic, was isolated as the major metabolite from a marine sponge Caulospongia biflabellata. Compound 1 exhibited potent cytotoxic activity against P388 and A549 tumor cells. The isolation, structure elucidation and biological activities of tubercidin (1) are described. This is the first report of the isolation of tubercidin from a marine organism. This author manuscript is an electronic version of an article published in Pharmaceutical Biology and may be cited as Biabani, Misbah F., Sarath P. Gunasekera, Ross E. Longley, Amy E. Wright and Shirley A. Pomponi (2002) Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata, Pharmaceutical Biology 40(4):302–303. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1470. |
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| Subject(s): |
Demospongiae Nucleosides --chemistry Cytotoxins --biosynthesis --congresses Streptomyces Antitumor antibiotics |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/2795916 | |
| Links: | https://doi.org/10.1076/phbi.40.4.302.8469 | |
| Restrictions on Access: | ©2002 Swets & Zeitlinger | |
| Host Institution: | FAU |
