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Pathogenesis of idiopathic restrictive cardiomyopathy
| Title: | Pathogenesis of idiopathic restrictive cardiomyopathy. |
 163 views 41 downloads |
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| Name(s): |
Li, Yuejin Charles E. Schmidt College of Medicine Department of Biomedical Science |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Issued: | 2011 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: | electronic | |
| Extent: | xii, 85 p. : ill. (some col.) | |
| Language(s): | English | |
| Summary: | Restrictive cardiomyopathy (RCM) is a heart muscle disease, characterized by diastolic dysfunction. The present dissertation is to understand the mechanisms underlyijng the initiation of diastolic dysfunction and the fast disease progression to early death in a RCM mouse model, the transgenic cTnI193His mouse... These data showed that myocardial ischemia occurred after diastolic dysfunction and before systolic dysfunction which proceeded congestive heart failure. The results demonstrate that myocardial ischemia causing cardiomycete death is a link between the initial diastolic dysfunction and late-stage systolic dysfunction, and accelerates the disease progression to fatal heart failure in the early age. | |
| Identifier: | 856904736 (oclc), 3362045 (digitool), FADT3362045 (IID), fau:4159 (fedora) | |
| Note(s): |
by Yuejin Li. Thesis (Ph.D.)--Florida Atlantic University, 2011. Includes bibliography. Mode of access: World Wide Web. System requirements: Adobe Reader. |
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| Subject(s): |
Mice as laboratory animals Heart conduction system Cardiovascular system -- Diseases -- Genetic aspects |
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| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3362045 | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
