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Dosimetric and Radiobiological Plan Evaluation Parameters for Fractionated High-Dose Rate GYN Brachytherapy
| Title: | Dosimetric and Radiobiological Plan Evaluation Parameters for Fractionated High-Dose Rate GYN Brachytherapy. |
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| Name(s): |
Shojaei, Marjan, author Pella, Silvia, Thesis advisor Leventouri, Theodora, Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Science Department of Physics |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2018 | |
| Date Issued: | 2018 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 61 p. | |
| Language(s): | English | |
| Abstract/Description: | Intracavitary high-dose-rate brachytherapy (HDRBT) is a treatment option for endometrial cancer, depending on the cancer stage. Because of the steep high dose gradient of HDRBT, very small differences in the treatment plans, surrounding organ’s anatomy, or procedures during the treatment could potentially cause significant dose variation to the tumor, as well as organs at risks (OAR) nearby the treatment area, which could result in unwanted radiobiological side effects. In this retrospective study, the radiobiological plan evaluation parameters Equivalent Uniform Dose (EUD), Normal Tissue Complication Probability (NTCP) are used as assessment tools to evaluate HDRBT plans. Furthermore, gynecological applicator position in the coordinate system, and possible dose variations to the tumor and critical organs from the initial fraction in comparison with subsequent fractions over the entire multi fractionated treatment are studied. The evaluations were performed for 118 HDR treatment plans for 30 patients by registration of the subsequent treatment plans into the initial CT-image guided plan. Dose fractionation regimens varied from 4Gy to 7Gy per fraction, 1 or 2 fractions per week, depending on the cancer stage. Our results demonstrate no significant radiobiological impacts on organs at risks (OAR). In addition, the results of the applicator positions’ study indicate that improvement of immobilization and localization devices are recommended. | |
| Identifier: | FA00013144 (IID) | |
| Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2018. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Brachytherapy Radiobiology Radiation dosimetry--Evaluation |
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| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00013144 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
