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Neuronal autophagy activity is essential for insulin growth factor signaling-regulated lifespan extension in C. elegans
- Date Issued:
- 2015
- Summary:
- The conserved insulin growth factor IGF signaling pathway is one of the major regulators of lifespan in many species including C. elegans. In C. elegans the insulin/IGF-like receptor is encoded by the daf-2 gene, mutations in which result in lifespan extension. The daf-2 activity in the nervous system controls these phenotypes cell nonautonomously. Interestingly, the longevity phenotype of daf-2 mutant worms is dependent on macroautophagy hereafter autophagy. Autophagy is a highly conserved lysosomal degradation pathway involved in the removal of long-lived proteins and cytoplasmic organelles. During autophagy, cellular components are sequestered into the double-membrane autophagosomes and delivered to lysosomes for degradation. Increasing evidence has emerged that the autophagy process is a central regulator of lifespan that is required for the effects of DAF-2 signaling, dietary restriction and some mitochondrial mutations on C. elegans longevity. It is unknown however whether autophagy activity in every tissue or in a single tissue mediates the influence of these longevity signals. To address this question, we examined the tissue requirement of the autophagy gene atg-18 for the lifespan of wild type animals and the daf-2 mutant. We discovered that neurons and intestinal cells are two key tissues where atg-18 mediates the effect of DAF-2 insulin-like signaling on lifespan, suggesting autophagy acts cell nonautonomously in controlling C. elegans adult longevity. Moreover, we found that neuronal release of neuropeptides is required for the cell non-autonomous function of neuronal autophagy activity in controlling C. elegans lifespan.
Title: | Neuronal autophagy activity is essential for insulin growth factor signaling-regulated lifespan extension in C. elegans. |
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Name(s): |
Minnerly, Justin Jia, Kailiang Zhang, Jiuli Graduate College |
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Type of Resource: | text | |
Genre: | Poster | |
Date Created: | 2015 | |
Date Issued: | 2015 | |
Publisher: | Florida Atlantic University | |
Place of Publication: | Boca Raton, Fla. | |
Physical Form: | application/pdf | |
Extent: | 1 p. | |
Language(s): | English | |
Summary: | The conserved insulin growth factor IGF signaling pathway is one of the major regulators of lifespan in many species including C. elegans. In C. elegans the insulin/IGF-like receptor is encoded by the daf-2 gene, mutations in which result in lifespan extension. The daf-2 activity in the nervous system controls these phenotypes cell nonautonomously. Interestingly, the longevity phenotype of daf-2 mutant worms is dependent on macroautophagy hereafter autophagy. Autophagy is a highly conserved lysosomal degradation pathway involved in the removal of long-lived proteins and cytoplasmic organelles. During autophagy, cellular components are sequestered into the double-membrane autophagosomes and delivered to lysosomes for degradation. Increasing evidence has emerged that the autophagy process is a central regulator of lifespan that is required for the effects of DAF-2 signaling, dietary restriction and some mitochondrial mutations on C. elegans longevity. It is unknown however whether autophagy activity in every tissue or in a single tissue mediates the influence of these longevity signals. To address this question, we examined the tissue requirement of the autophagy gene atg-18 for the lifespan of wild type animals and the daf-2 mutant. We discovered that neurons and intestinal cells are two key tissues where atg-18 mediates the effect of DAF-2 insulin-like signaling on lifespan, suggesting autophagy acts cell nonautonomously in controlling C. elegans adult longevity. Moreover, we found that neuronal release of neuropeptides is required for the cell non-autonomous function of neuronal autophagy activity in controlling C. elegans lifespan. | |
Identifier: | FA00005900 (IID) | |
Collection: | FAU Student Research Digital Collection | |
Note(s): | The Sixth Annual Graduate Research Day was organized by Florida Atlantic University’s Graduate Student Association. Graduate students from FAU Colleges present abstracts of original research and posters in a competition for monetary prizes, awards, and recognition. | |
Held by: | Florida Atlantic University Libraries | |
Sublocation: | Digital Library | |
Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00005900 | |
Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
Host Institution: | FAU | |
Is Part of Series: | Florida Atlantic University Digital Library Collections. |