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Isolation and Biomimetic Synthesis of Marine Natural Products
| Title: | Isolation and Biomimetic Synthesis of Marine Natural Products. |
 89 views 18 downloads |
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| Name(s): |
Williams, Shakia Gulino, Stephanie Bari, Arafat West, Lyndon Office of Undergraduate Research and Inquiry |
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| Type of Resource: | text | |
| Genre: | Poster | |
| Date Created: | 2017 | |
| Date Issued: | 2017 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Florida | |
| Physical Form: | application/pdf | |
| Extent: | 1 p. | |
| Language(s): | English | |
| Summary: | While natural products have served as a prolific source of unique chemistry, supply remains a significant obstacle for drug discovery. The overall goal of this project is to determine whether isolation and semi-synthesis can provide adequate quantities for biological evaluation. Erythropodium caribaeorum is an abundant gorgonian in the Caribbean that produces two unique marine diterpenoids, erythrolides A and B, which have been shown to undergo photochemical transformations to yield more complex chemistry. In this project, erythrolides A and B will be isolated from E. caribaeorum collected off the coast of Boca Raton, Florida. These compounds will be exposed to ultraviolet light and analyzed to identify any chemical changes. New compounds will then be subjected to biological screening for cytotoxicity against human cancer cell lines. This project will not only identify new bioactive compounds but also provide a novel route for the large-scale production of medically relevant marine natural products. | |
| Identifier: | FA00005640 (IID) | |
| Subject(s): | College students --Research --United States. | |
| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00005640 | |
| Restrictions on Access: | Author retains rights. | |
| Host Institution: | FAU |
