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Angiographic Changes of Blood Vessels in the Photoreceptor Degenerative Mouse Retina

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Date Issued:
2016
Summary:
Tortuous, or twisted, arteries and veins are commonly observed in humans and animals diagnosed with diseases caused by the degeneration of photoreceptor cells. However, the mechanisms of their formation and development are poorly understood. We used immunocytochemical, confocal imaging and computer remodeling techniques to map the angiographic changes in the photoreceptor degenerative mouse model, pde6d (rd1) mice. We found that mechanical instability and rewiring in the distal retina of rd1 mice could be mechanisms for the initiation and development of these tortuous vessels. We also found that in the late stages of retinal degeneration, severe tortuosity leads to ischemic attack in the distal retina. This study provides valuable insights into understanding the pathologic changes of retinal blood vessels in the development of diseases in humans and animals.
Title: Angiographic Changes of Blood Vessels in the Photoreceptor Degenerative Mouse Retina.
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Name(s): Nguyen, Matthew
Shen, Wen
Office of Undergraduate Research and Inquiry
Type of Resource: text
Genre: Poster
Date Created: 2016
Date Issued: 2016
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Florida
Physical Form: application/pdf
Extent: 1 p.
Language(s): English
Summary: Tortuous, or twisted, arteries and veins are commonly observed in humans and animals diagnosed with diseases caused by the degeneration of photoreceptor cells. However, the mechanisms of their formation and development are poorly understood. We used immunocytochemical, confocal imaging and computer remodeling techniques to map the angiographic changes in the photoreceptor degenerative mouse model, pde6d (rd1) mice. We found that mechanical instability and rewiring in the distal retina of rd1 mice could be mechanisms for the initiation and development of these tortuous vessels. We also found that in the late stages of retinal degeneration, severe tortuosity leads to ischemic attack in the distal retina. This study provides valuable insights into understanding the pathologic changes of retinal blood vessels in the development of diseases in humans and animals.
Identifier: FA00005594 (IID)
Subject(s): College students --Research --United States.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00005594
Restrictions on Access: Author retains rights.
Host Institution: FAU