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The Effect of Inactivation of the Nucleus Reuniens on Spatial Working Memory

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Date Issued:
2016
Summary:
The Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested Long Evan rats using a T-maze. For each trial the rats were required to alternate between the left and right goal arms with a delay period in between randomized intervals of 30s, 60s, or 120s. After two consecutive testing days of 80% the rats were infused with muscimol procaine, and saline. We expect that the effect of reversible inactivation of RE will demonstrate a significant decline in performance of the task.
Title: The Effect of Inactivation of the Nucleus Reuniens on Spatial Working Memory.
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Name(s): Martinez Rey, Macarena
Minnerly, Christopher
Vertes, Robert P.
Office of Undergraduate Research and Inquiry
Type of Resource: text
Genre: Poster
Date Created: 2016
Date Issued: 2016
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Florida
Physical Form: application/pdf
Extent: 1 p.
Language(s): English
Summary: The Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested Long Evan rats using a T-maze. For each trial the rats were required to alternate between the left and right goal arms with a delay period in between randomized intervals of 30s, 60s, or 120s. After two consecutive testing days of 80% the rats were infused with muscimol procaine, and saline. We expect that the effect of reversible inactivation of RE will demonstrate a significant decline in performance of the task.
Identifier: FA00005588 (IID)
Subject(s): College students --Research --United States.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00005588
Restrictions on Access: Author retains rights.
Host Institution: FAU