You are here

2-Hydroxychalcone as a Unique Luminescent Probe (ESIPT) for Peptides Labeling

Download pdf | Full Screen View

Date Issued:
2016
Summary:
Peptides and proteins with photochemical sensors are valuable tools when analyzing biochemical processes and peptide properties. Recent work on fluorescent α-amino acids (FlAAs) proved extremely useful in studying protein folding, conformational changes and reactivity. When fluorescent tags are appropriately attached to proteins they allow for the detection of their environment and changes therein. Research on the topic of site-specific fluorescent molecules is in its early stages. Several challenges face the topic of selectively excitable fluorescent probes. These include limits on the size and lifetime of synthesized proteins and enzymes, attaching the tag at the target location on a peptide chain which will take advantage of the photochemical properties of the tag, and developing molecules that will readily exhibit environment-sensitive fluorescence.
Title: 2-Hydroxychalcone as a Unique Luminescent Probe (ESIPT) for Peptides Labeling.
52 views
1 downloads
Name(s): Kempton, Thomas G.
Samanta, Shyam S.
Roche, Stéphane P.
Office of Undergraduate Research and Inquiry
Type of Resource: text
Genre: Poster
Date Created: 2016
Date Issued: 2016
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Florida
Physical Form: application/pdf
Extent: 1 p.
Language(s): English
Summary: Peptides and proteins with photochemical sensors are valuable tools when analyzing biochemical processes and peptide properties. Recent work on fluorescent α-amino acids (FlAAs) proved extremely useful in studying protein folding, conformational changes and reactivity. When fluorescent tags are appropriately attached to proteins they allow for the detection of their environment and changes therein. Research on the topic of site-specific fluorescent molecules is in its early stages. Several challenges face the topic of selectively excitable fluorescent probes. These include limits on the size and lifetime of synthesized proteins and enzymes, attaching the tag at the target location on a peptide chain which will take advantage of the photochemical properties of the tag, and developing molecules that will readily exhibit environment-sensitive fluorescence.
Identifier: FA00005580 (IID)
Subject(s): College students --Research --United States.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00005580
Restrictions on Access: Author retains rights.
Owner Institution: FAU