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Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity
- Date Issued:
- 2007
- Summary:
- Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy. We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina. The mouse ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen for five days, then were given intraocular injection of IL-100 and NV was evaluated after seven days in room air. Controls were uninjected contralateral eyes. IL-l 0 strongly inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and possibly, in AMD where inflammation is a risk factor.
Title: | Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity. |
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Name(s): |
Solomon, Evertz Stenson Blanks, Janet C., Thesis advisor Florida Atlantic University, Degree grantor |
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Type of Resource: | text | |
Genre: | Electronic Thesis Or Dissertation | |
Date Created: | 2007 | |
Date Issued: | 2007 | |
Publisher: | Florida Atlantic University | |
Place of Publication: | Boca Raton, Fla. | |
Physical Form: | application/pdf | |
Extent: | 47 p. | |
Language(s): | English | |
Summary: | Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy. We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina. The mouse ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen for five days, then were given intraocular injection of IL-100 and NV was evaluated after seven days in room air. Controls were uninjected contralateral eyes. IL-l 0 strongly inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and possibly, in AMD where inflammation is a risk factor. | |
Identifier: | FA00000833 (IID) | |
Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2007. | |
Collection: | FAU Electronic Theses and Dissertations Collection | |
Note(s): |
Includes bibliography. Charles E. Schmidt College of Medicine |
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Subject(s): |
Neovascularization Neovascularization inhibitors Interleukin-10 |
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Held by: | Florida Atlantic University Libraries | |
Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00000833 | |
Sublocation: | Digital Library | |
Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
Host Institution: | FAU | |
Is Part of Series: | Florida Atlantic University Digital Library Collections. |