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Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training

Title: Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.
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Name(s): Ash, Garrett I., author
Kostek, Matthew A., author
Lee, Harold, author
Angelopoulos, Theodore J., author
Clarkson, Priscilla M., author
Gordon, Paul M., author
Moyna, Niall M., author
Visich, Paul S., author
Zoeller, Robert F., author
Price, Thomas B., author
Devaney, Joseph M., author
Gordish-Dressman, Heather, author
Thompson, Paul D., author
Hoffman, Eric P., author
Pescatello, Linda S., author
Fine, Michael L, editor
Type of Resource: text
Genre: Article
Date Issued: 2016-01-28
Summary: Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm^2) preand post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol’s actions in muscle tissue as they interact with sex differences in cortisol production.
Identifier: 10.1371/journal.pone.0148112 (doi), http://dx.plos.org/10.1371/journal.pone.0148112 (uri), FAUIR000062 (IID)
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FAUIR000062
Use and Reproduction: publisher
Host Institution: FAU
Is Part Of: PLOS ONE.
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