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The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration

Title: The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.
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Name(s): Grill, Brock, author
Murphey, Rodney K., author
Borgen, Melissa A., author
Type of Resource: text
Genre: Article
Date Issued: 2016-12-23
Summary: During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR function across species, as well as the myriad of signaling pathways PHR proteins regulate. These findings collectively suggest that the PHR proteins are intracellular signaling hubs, a concept we explore in depth. Consistent with prominent developmental functions, genetic links have begun to emerge between PHR signaling networks and neurodevelopmental disorders, such as autism, schizophrenia and intellectual disability. Finally, we discuss the recent and important finding that PHR proteins regulate axon degeneration, which has further heightened interest in this fascinating group of molecules.
Identifier: 10.1186/s13064-016-0063-0 (doi), http://neuraldevelopment.biomedcentral.com/articles/10.1186/s13064-016-0063-0 (uri), FAUIR000039 (IID)
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FAUIR000039
Use and Reproduction: publisher
Host Institution: FAU
Is Part Of: Neural Development.
1749-8104