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Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro
| Title: | Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro. |
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| Name(s): |
Carraher, Charles E., author Roner, Michael R., author Shahi, Kimberly, author Barot, Girish, author |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2011-04-15 | |
| Summary: | The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth. | |
| Identifier: | 10.3390/ma4040801 (doi), http://www.mdpi.com/1996-1944/4/4/801/ (uri), FAUIR000009 (IID) | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FAUIR000009 | |
| Use and Reproduction: | publisher | |
| Host Institution: | FAU | |
| Is Part Of: |
Materials. 1996-1944 |
